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PXD002848

PXD002848 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGenomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome
DescriptionSCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using a chemo-proteomic approach. SILAC-based proteomic studies using an oxaborole analogue immobilised onto a resin was used either in competition with a soluble oxaborole or an immobilised inactive control to identify thirteen proteins common to both strategies. The diverse list of binding partners from the proteomic studies suggest a degree of polypharmacology that should reduce the risk of resistance to this compound class emerging in the field.
HostingRepositoryPRIDE
AnnounceDate2015-11-25
AnnouncementXMLSubmission_2016-01-04_14:25:44.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterMichael Urbaniak
SpeciesList scientific name: Trypanosoma brucei; NCBI TaxID: 5691;
ModificationListmonohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-09-04 01:57:13ID requested
12015-11-25 05:49:02announced
22016-01-04 14:25:45announcedUpdated publication reference for PubMed record(s): 26684831.
Publication List
Jones DC, Foth BJ, Urbaniak MD, Patterson S, Ong HB, Berriman M, Fairlamb AH, Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome. PLoS Negl Trop Dis, 9(12):e0004299(2015) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Trypanosoma brucei
Contact List
Alan Fairlamb
contact affiliationDivision of Biological Chemistry & Drug Discovery University of Dundee
contact emaila.h.fairlamb@dundee.ac.uk
lab head
Michael Urbaniak
contact affiliationLancaster University
contact emailm.urbaniak@lancaster.ac.uk
dataset submitter
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Dataset FTP location
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