PXD002848 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome |
Description | SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using a chemo-proteomic approach. SILAC-based proteomic studies using an oxaborole analogue immobilised onto a resin was used either in competition with a soluble oxaborole or an immobilised inactive control to identify thirteen proteins common to both strategies. The diverse list of binding partners from the proteomic studies suggest a degree of polypharmacology that should reduce the risk of resistance to this compound class emerging in the field. |
HostingRepository | PRIDE |
AnnounceDate | 2015-11-25 |
AnnouncementXML | Submission_2016-01-04_14:25:44.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Michael Urbaniak |
SpeciesList | scientific name: Trypanosoma brucei; NCBI TaxID: 5691; |
ModificationList | monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-09-04 01:57:13 | ID requested | |
1 | 2015-11-25 05:49:02 | announced | |
⏵ 2 | 2016-01-04 14:25:45 | announced | Updated publication reference for PubMed record(s): 26684831. |
Publication List
Jones DC, Foth BJ, Urbaniak MD, Patterson S, Ong HB, Berriman M, Fairlamb AH, Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome. PLoS Negl Trop Dis, 9(12):e0004299(2015) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Trypanosoma brucei |
Contact List
Alan Fairlamb |
contact affiliation | Division of Biological Chemistry & Drug Discovery University of Dundee |
contact email | a.h.fairlamb@dundee.ac.uk |
lab head | |
Michael Urbaniak |
contact affiliation | Lancaster University |
contact email | m.urbaniak@lancaster.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/11/PXD002848 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002848
- Label: PRIDE project
- Name: Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome