PXD002780

PXD002780 is an original dataset announced via ProteomeXchange.

Title	Exonuclease-1 interactome and phosphorylation sites
Description	To help shedding light on regulatory aspects of DNA repair and remodeling pathways in which EXO1 participates and to help revealing novel cellular processes in which EXO1 is involved, we set out to identify proteins interacting with EXO1. Both a small-scale approach and a comprehensive analysis of the EXO1 interactome allowed identifying novel protein partners that are involved in RNA processing or that are the causative agents of rare X-linked disorders. Follow-up biochemical studies allowed validating the direct interaction with selected proteins. Extensive coverage of EXO1 sequence (>85%) allowed conducting an in-depth analysis of its phosphorylation sites, with the identification of 26 residues that are differentially modified in untreated conditions or upon induction of DNA damage.
HostingRepository	PRIDE
AnnounceDate	2019-01-31
AnnouncementXML	Submission_2019-06-03_01:34:10.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Daniel Hess
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue; monohydroxylated residue; acetylated residue; deamidated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-08-24 01:33:48	ID requested
1	2019-01-31 07:51:33	announced
⏵ 2	2019-06-03 01:34:11	announced	Updated publication reference for PubMed record(s): 31056253.

Eid W, Hess D, K, ö, nig C, Gentili C, Ferrari S, The human Exonuclease-1 interactome and phosphorylation sites. Biochem Biophys Res Commun, 514(3):567-573(2019) [pubmed]

curator keyword: Biological

submitter keyword: Human, EXO1, affinity tag purification, phosphorylation

Daniel Hess
contact affiliation	Friedrich Miescher Institute for Biomedical Research Maulbeerstr. 66 CH-4058 BASEL
contact email	dhess@fmi.ch
lab head
Daniel Hess
contact affiliation	Friedrich Miescher Institute for Biomedical Research
contact email	dhess@fmi.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/01/PXD002780

PRIDE project URI

• PRIDE
  1. PXD002780
     1. Label: PRIDE project
     2. Name: Exonuclease-1 interactome and phosphorylation sites