PXD002733

PXD002733 is an original dataset announced via ProteomeXchange.

Title	Proteomic profile of deleted in breast cancer 1 protein-protein interactions
Description	Deleted in breast cancer 1 (DBC1) has emerged as an important regulator of multiple cellular processes, ranging from gene expression to cell cycle progression. DBC1 has been linked to tumorigenesis both as an inhibitor of histone deacetylases (HDAC), HDAC3 and sirtuin 1 (SIRT1), and as a transcriptional cofactor for nuclear hormone receptors. However, despite mounting interest in DBC1, relatively little is known about the range of its interacting partners and the scope of its functions. DBC1 protien interactions were studied in two cell types, T cells and HEK293 kidney cells
HostingRepository	PRIDE
AnnounceDate	2015-12-17
AnnouncementXML	Submission_2015-12-17_04:55:15.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	T Greco
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue; monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue; phosphorylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-08-17 01:35:14	ID requested
⏵ 1	2015-12-17 04:55:16	announced

Gigu, è, re SS, Guise AJ, Jean Beltran PM, Joshi PM, Greco TM, Quach OL, Kong J, Cristea IM, The Proteomic Profile of Deleted in Breast Cancer 1 (DBC1) Interactions Points to a Multifaceted Regulation of Gene Expression. Mol Cell Proteomics, 15(3):791-809(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: affinity purification, protein interactions, SAINT, HDAC, SIRT

Ileana M Cristea
contact affiliation	Molecular Biology, Princeton University, USA
contact email	icristea@princeton.edu
lab head
T Greco
contact affiliation	Molecular Biology
contact email	tgreco@princeton.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/12/PXD002733

PRIDE project URI

• PRIDE
  1. PXD002733
     1. Label: PRIDE project
     2. Name: Proteomic profile of deleted in breast cancer 1 protein-protein interactions