⮝ Full datasets listing

PXD002690

PXD002690 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleLarge scale profiling of the physiological impact of a potent anti-cancer agent inhibiting early protein maturation
DescriptionFumagillin and its derivatives are therapeutically-useful compounds for their capacity to reduce cancer progression. Fumagillin exerts a specific proliferation inhibition on endothelial cell lines and on several tumor lines. The specific molecular target of fumagillin is MetAP2, one of the two cytosolic MetAPs. MetAPs are in charge of N-terminal Methionine Excision, an essential pathway of cotranslational protein maturation. Why the inhibition of MetAP2 causes cell growth arrest in a subset class of cells is yet unknown. Here, we focus on a global large scale characterization of the N-terminal Methionine Excision pathway and the inhibition of one of its enzymes by fumagillin in a number of lines including cancer cell lines. N-termini profiling of responsive and unresponsive cells to fumagillin treatment was conducted using large scale proteomics approach
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_03:58:31.131.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterWilly Bienvenut
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList(R)-5-oxo-1; potassium containing modified residue; acetate labeling reagent (N-term) (heavy form, +3amu); 3x(2)H labeled N6-acetyl-L-lysine; phosphorylated residue; mono N-acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-08-10 02:12:40ID requested
12017-01-02 07:02:30announced
22017-10-24 04:12:15announcedUpdated project metadata.
32024-10-22 03:58:37announced2024-10-22: Updated project metadata.
Publication List
10.18632/oncotarget.11216;
Frottin F, Bienvenut WV, Bignon J, Jacquet E, Vaca Jacome AS, Van Dorsselaer A, Cianferani S, Carapito C, Meinnel T, Giglione C, MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state. Oncotarget, 7(39):63306-63323(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: co-translational modifications
N-terminal processing
methionine aminopeptidase
N-α-acetyltransferase
N-myristoyltransferase
drug evaluation;
Contact List
Willy V Bienvenut
contact affiliationInstitute of Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Avenue de la Terrasse, F-91198 Gif-sur-Yvette cedex, France
contact emailwilly.bienvenut@i2bc.paris-saclay.fr
lab head
Willy Bienvenut
contact affiliationCNRS
contact emailwilly.bienvenut@universite-paris-saclay.fr
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/01/PXD002690
PRIDE project URI
Repository Record List
[ + ]