PXD002690 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Large scale profiling of the physiological impact of a potent anti-cancer agent inhibiting early protein maturation |
Description | Fumagillin and its derivatives are therapeutically-useful compounds for their capacity to reduce cancer progression. Fumagillin exerts a specific proliferation inhibition on endothelial cell lines and on several tumor lines. The specific molecular target of fumagillin is MetAP2, one of the two cytosolic MetAPs. MetAPs are in charge of N-terminal Methionine Excision, an essential pathway of cotranslational protein maturation. Why the inhibition of MetAP2 causes cell growth arrest in a subset class of cells is yet unknown. Here, we focus on a global large scale characterization of the N-terminal Methionine Excision pathway and the inhibition of one of its enzymes by fumagillin in a number of lines including cancer cell lines. N-termini profiling of responsive and unresponsive cells to fumagillin treatment was conducted using large scale proteomics approach |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_03:58:31.131.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Willy Bienvenut |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | (R)-5-oxo-1; potassium containing modified residue; acetate labeling reagent (N-term) (heavy form, +3amu); 3x(2)H labeled N6-acetyl-L-lysine; phosphorylated residue; mono N-acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-08-10 02:12:40 | ID requested | |
1 | 2017-01-02 07:02:30 | announced | |
2 | 2017-10-24 04:12:15 | announced | Updated project metadata. |
⏵ 3 | 2024-10-22 03:58:37 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.18632/oncotarget.11216; |
Frottin F, Bienvenut WV, Bignon J, Jacquet E, Vaca Jacome AS, Van Dorsselaer A, Cianferani S, Carapito C, Meinnel T, Giglione C, MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state. Oncotarget, 7(39):63306-63323(2016) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: co-translational modifications |
N-terminal processing |
methionine aminopeptidase |
N-α-acetyltransferase |
N-myristoyltransferase |
drug evaluation; |
Contact List
Willy V Bienvenut |
contact affiliation | Institute of Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, Avenue de la Terrasse, F-91198 Gif-sur-Yvette cedex, France |
contact email | willy.bienvenut@i2bc.paris-saclay.fr |
lab head | |
Willy Bienvenut |
contact affiliation | CNRS |
contact email | willy.bienvenut@universite-paris-saclay.fr |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/01/PXD002690 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002690
- Label: PRIDE project
- Name: Large scale profiling of the physiological impact of a potent anti-cancer agent inhibiting early protein maturation