PXD002676

PXD002676 is an original dataset announced via ProteomeXchange.

Title	Proteomic and bioinformatic analysis of the nuclear intrinsically disordered proteome
Description	Intrinsically disordered proteins (IDPs) are biologically active molecules which are involved in many cellular functions although they do not possess a defined three-dimensional structure. They are mostly signalling and regulatory proteins. This study is the first large-scale proteomic analysis of the nuclear IDPs. We experimentally showed that IDPs are overrepresented in the nucleus in comparison to the whole cell. The analysis in terms of molecular function indicated that nuclear intrinsically disordered proteome (IDP-ome) is enriched in proteins involved in transcription regulation and especially in transcription factors.
HostingRepository	PRIDE
AnnounceDate	2015-09-21
AnnouncementXML	Submission_2015-09-21_03:51:02.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002676
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Bozena Skupien-Rabian
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	micrOTOF-Q II

Revision	Datetime	Status	ChangeLog Entry
0	2015-08-06 01:14:27	ID requested
⏵ 1	2015-09-21 03:51:03	announced

Skupien-Rabian B, Jankowska U, Swiderska B, Lukasiewicz S, Ryszawy D, Dziedzicka-Wasylewska M, Kedracka-Krok S, Proteomic and bioinformatic analysis of a nuclear intrinsically disordered proteome. J Proteomics, 130():76-84(2016) [pubmed]

curator keyword: Biological

submitter keyword: intrinsically disordered proteins, nuclear proteome, subproteome, transcription factors

Sylwia Kedracka-Krok
contact affiliation	1. Department of Structural Biology, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland 2. Department of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
contact email	sylwia.kedracka-krok@uj.edu.pl
lab head
Bozena Skupien-Rabian
contact affiliation	1. Department of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland 2. Department of Structural Biology, Malopolska Centre of Biotechnology, Jagiellonian University, Krakow, Poland
contact email	bozena.skupien-rabian@uj.edu.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/09/PXD002676

PRIDE project URI

• PRIDE
  1. PXD002676
     1. Label: PRIDE project
     2. Name: Proteomic and bioinformatic analysis of the nuclear intrinsically disordered proteome