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PXD002650

PXD002650 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleEndothelial cell proteomic response to Rickettsia conorii infection
DescriptionRickettsia conorii is the etiologic agent of Mediterranean spotted fever, a re-emerging disease with significant mortality. This obligate, gram-negative intracellular pathogen is transmitted via tick bites, resulting in disseminated vascular endothelial cell infection with vascular leakage. In the infected human, Rickettsia conorii infects endothelial cells, stimulating expression of cytokines and pro-coagulant factors. However, the integrated proteomic response of human endothelial cells to R. conorii infection is not known. In this study, we performed quantitative proteomic profiling of R conorii –infected primary HUVECs vs those stimulated with LPS alone.
HostingRepositoryPRIDE
AnnounceDate2015-11-17
AnnouncementXMLSubmission_2015-11-17_05:17:54.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYingxin Zhao
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-08-03 01:01:51ID requested
12015-11-17 05:17:55announced
Publication List
Keyword List
curator keyword: Biomedical
submitter keyword: Endothelial cell, Rickettsia conorii, LC-MS/MS
Contact List
Allan R. Brasier
contact affiliationUniversity of Texas Medical Branch
contact emailarbrasier@utmb.edu
lab head
Yingxin Zhao
contact affiliationUniversity of Texas Medical Branch
contact emailyizhao@utmb.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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