PXD002629 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Human γδ T-cell, LC-MS/MS - Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor |
Description | A new method of graft manipulation based on physical removal of αβ+ T cells and CD19+ B cells, leaving mature NK cells and γδ T cells in the graft, has been recently developed for HLA-haploidentical HSCT. We demonstrated that γδ T cells collected from transplanted patients are endowed with capacity of killing leukemia cells after ex vivo treatment with zoledronic acid (ZOL). Thus, we hypothesized that infusion of ZOL in patients receiving this type of graft, may boost γδ T cell cytotoxic activity against acute leukemia blasts. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:05:00.200.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andrea Petretto |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-07-29 07:19:29 | ID requested | |
1 | 2018-10-24 10:33:10 | announced | |
⏵ 2 | 2024-10-22 04:05:08 | announced | 2024-10-22: Updated project metadata. |
Publication List
Bertaina A, Zorzoli A, Petretto A, Barbarito G, Inglese E, Merli P, Lavarello C, Brescia LP, De Angelis B, Tripodi G, Moretta L, Locatelli F, Airoldi I, cell-depleted grafts from an HLA-haplo-identical donor. Oncoimmunology, 6(2):e1216291(2017) [pubmed] |
10.1080/2162402X.2016.1216291; |
Keyword List
curator keyword: Biomedical |
submitter keyword: Human,γδ T-cell, Leukemia Cells, Zolendric Acid (ZOL) |
Contact List
Andrea Petretto |
contact affiliation | Gaslini Children's Hospital |
contact email | a.petretto@gmail.com |
lab head | |
Andrea Petretto |
contact affiliation | Gaslini Children's Hospital |
contact email | a.petretto@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002629
- Label: PRIDE project
- Name: Human γδ T-cell, LC-MS/MS - Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor