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PXD002629

PXD002629 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHuman γδ T-cell, LC-MS/MS - Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor
DescriptionA new method of graft manipulation based on physical removal of αβ+ T cells and CD19+ B cells, leaving mature NK cells and γδ T cells in the graft, has been recently developed for HLA-haploidentical HSCT. We demonstrated that γδ T cells collected from transplanted patients are endowed with capacity of killing leukemia cells after ex vivo treatment with zoledronic acid (ZOL). Thus, we hypothesized that infusion of ZOL in patients receiving this type of graft, may boost γδ T cell cytotoxic activity against acute leukemia blasts.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:05:00.200.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndrea Petretto
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue; deamidated residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-07-29 07:19:29ID requested
12018-10-24 10:33:10announced
22024-10-22 04:05:08announced2024-10-22: Updated project metadata.
Publication List
Bertaina A, Zorzoli A, Petretto A, Barbarito G, Inglese E, Merli P, Lavarello C, Brescia LP, De Angelis B, Tripodi G, Moretta L, Locatelli F, Airoldi I, cell-depleted grafts from an HLA-haplo-identical donor. Oncoimmunology, 6(2):e1216291(2017) [pubmed]
10.1080/2162402X.2016.1216291;
Keyword List
curator keyword: Biomedical
submitter keyword: Human,γδ T-cell, Leukemia Cells, Zolendric Acid (ZOL)
Contact List
Andrea Petretto
contact affiliationGaslini Children's Hospital
contact emaila.petretto@gmail.com
lab head
Andrea Petretto
contact affiliationGaslini Children's Hospital
contact emaila.petretto@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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