PXD002600

PXD002600 is an original dataset announced via ProteomeXchange.

Title	Protein expression in TKI-resistant RCC cells.
Description	Resistance to tyrosine kinase inhibitors is an essential issue concerning targeted therapy in renal cancer. This research focuses on molecular background of resistance to axitinib and sorafenib observed from the very beginning of a standard two-dimensional cell culture in monolayer as well as in three-dimensional models (soft agar and suspension cultures). Resistance was observed only in commercially available human kidney cancer stem cells. Mass spectrometry analysis revealed several proteins which may be functionally connected with the resistance to axitinib in normoxia and to sorafenib in hypoxia.
HostingRepository	PRIDE
AnnounceDate	2018-01-02
AnnouncementXML	Submission_2018-01-02_04:03:17.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002600
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Agata Malinowska
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methylthiolated residue; monohydroxylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-27 01:27:33	ID requested
⏵ 1	2018-01-02 04:03:19	announced

Bielecka ZF, Malinowska A, Brodaczewska KK, Klemba A, Kieda C, Krasowski P, Grzesiuk E, Piwowarski J, Czarnecka AM, Szczylik C, Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells. Cell Biosci, 7():71(2017) [pubmed]

submitter keyword: kidney cancer, stem cell, mass spectrometry, label free

Michal Dadlez
contact affiliation	Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
contact email	michald@ibb.waw.pl
lab head
Agata Malinowska
contact affiliation	IBB PAS
contact email	esme@ibb.waw.pl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/01/PXD002600

PRIDE project URI

• PRIDE
  1. PXD002600
     1. Label: PRIDE project
     2. Name: Protein expression in TKI-resistant RCC cells.