PXD002578

PXD002578 is an original dataset announced via ProteomeXchange.

Title	Rat liver ESI-MS/MS
Description	one-carbon metabolism in the liver plays a critical role in placental and fetal growth. Impaired functioning of one-carbon metabolism is associated with increased homocysteine (Hcy) levels. In this study, we applied a comprehensive proteomic approach to identify differential expression of proteins related to one-carbon metabolism in the livers of rat offspring as an effect of maternal food restriction during gestation. We determined that betaine-homocysteine S-methyltransferase 1 (BHMT1), methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), and ATP synthase subunit beta mitochondrial (ATP5B) expression levels were significantly reduced in the livers of rat offspring exposed to maternal food restriction during gestation compared with in the offspring of rats fed a normal diet (p<0.05).
HostingRepository	PRIDE
AnnounceDate	2015-09-07
AnnouncementXML	Submission_2015-09-07_07:44:10.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Young-Ah You
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	monohydroxylated residue
Instrument	electrospray ionization

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-21 05:04:08	ID requested
⏵ 1	2015-09-07 07:44:11	announced

You YA, Lee JH, Kwon EJ, Yoo JY, Kwon WS, Pang MG, Kim YJ, Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring. Mol Cell Proteomics, 14(11):2901-9(2015) [pubmed]

curator keyword: Biological

submitter keyword: rat, liver, ESI-MS/MS

Young-Ah, You
contact affiliation	Ewha Womans University, South Korea
contact email	yerang02@naver.com
lab head
Young-Ah You
contact affiliation	Ewha Womans University, south Korea
contact email	yerang02@naver.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/09/PXD002578

PRIDE project URI

• PRIDE
  1. PXD002578
     1. Label: PRIDE project
     2. Name: Rat liver ESI-MS/MS