PXD002554

PXD002554 is an original dataset announced via ProteomeXchange.

Title	Human platelet detergent resistant membranes proteome
Description	Here we characterized the proteins associated with detergent resistant membranes (DRMs) from resting and activated human platelets. We achieved a proteomic profile of 141 DRM proteins involved in many biological pathways including 'PAR-1-mediated thrombin signal events', 'Integrin family cell surface interactions', 'Platelet activation, signalling and aggregation' and 'Platelet degranulation'. Therefore, a high level of relevant platelet signalling and trafficking proteins were identified e.g., Rap 1b, Src, SNAP-23 and syntaxin-11, implicating platelet DRMs as concentrating platforms not only in the critical platelet function of activation but also in secretion/degranulation.
HostingRepository	PRIDE
AnnounceDate	2016-06-23
AnnouncementXML	Submission_2016-06-23_02:03:22.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Paulina Szklanna
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-17 08:41:07	ID requested
⏵ 1	2016-06-23 02:03:23	announced

Szklanna PB, Foy M, Wynne K, Byrne D, Maguire PB, Analysis of the proteins associated with platelet detergent resistant membranes. Proteomics, 16(17):2345-50(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Human, Platelets, Detergent resistant membranes, LC-MS/MS

Patricia B. Maguire
contact affiliation	School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Ireland
contact email	patricia.maguire@ucd.ie
lab head
Paulina Szklanna
contact affiliation	University College Dublin
contact email	paulina.szklanna@ucdconnect.ie
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/06/PXD002554

PRIDE project URI

• PRIDE
  1. PXD002554
     1. Label: PRIDE project
     2. Name: Human platelet detergent resistant membranes proteome