PXD002535

PXD002535 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Middle-down MS analysis of intact and clipped histone H3 proteoforms
Description	There is growing evidence that proteolytic cleavage of histone N-terminal tails, known as histone clipping, influences nucleosome dynamics and functional properties. Using middle-down MS analysis we characterized intact and proteolytically processed histone H3 proteoforms isolated from human hepatocarcinoma cell line HepG2/C3A grown in 3D culture.
HostingRepository	PRIDE
AnnounceDate	2024-10-07
AnnouncementXML	Submission_2024-10-07_13:28:13.398.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andrey Tvardovskiy
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monomethylated residue; phosphorylated residue; acetylated residue; dimethylated residue; N6,N6,N6-trimethyl-L-lysine
Instrument	LTQ Orbitrap Velos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-14 01:15:48	ID requested
⏵ 1	2024-10-07 13:28:14	announced

Publication List

Tvardovskiy A, Wrzesinski K, Sidoli S, Fey SJ, Rogowska-Wrzesinska A, Jensen ON, Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns. Mol Cell Proteomics, 14(12):3142-53(2015) [pubmed]
10.1074/mcp.m115.048975;

Tvardovskiy A, Wrzesinski K, Sidoli S, Fey SJ, Rogowska-Wrzesinska A, Jensen ON, Top-down and Middle-down Protein Analysis Reveals that Intact and Clipped Human Histones Differ in Post-translational Modification Patterns. Mol Cell Proteomics, 14(12):3142-53(2015) [pubmed]

10.1074/mcp.m115.048975;

Keyword List

curator keyword: Biological
submitter keyword: liver, Hepg2/C3A,Middle-down MS, Histone post-translational modifications

curator keyword: Biological

submitter keyword: liver, Hepg2/C3A,Middle-down MS, Histone post-translational modifications

Contact List

Ole Nørregaard Jensen
contact affiliation	Department of Biochemistry and Molecular Biology, Protein Research Group, University of Southern Denmark
contact email	jenseno@bmb.sdu.dk
lab head
Andrey Tvardovskiy
contact affiliation	University of Southern Denmark
contact email	antvar@bmb.sdu.dk
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD002535
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD002535

PRIDE project URI

Repository Record List

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