PXD002486

PXD002486 is an original dataset announced via ProteomeXchange.

Title	Target identification for 11q13 amplicon
Description	Proteomic strategy to define therapeutically relevant targets in cell lines that contain the 11q13 amplicon compared to those that do not and to ascertain which genes are amplified at the protein level and, concomitantly, are key drivers for tumor growth and/or maintenance. Furthermore, so called passenger genes that are amplified with driver genes and a manifest on the cell surface can be attractive targets for an antibody – drug conjugate approach (ADC).
HostingRepository	PRIDE
AnnounceDate	2015-08-04
AnnouncementXML	Submission_2015-08-04_07:35:52.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002486
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Heather Hoover
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Phospho; Oxidation; TMT6plex; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-06 05:32:30	ID requested
⏵ 1	2015-08-04 07:35:53	announced

Hoover H, Li J, Marchese J, Rothwell C, Borawoski J, Jeffery DA, Gaither LA, Finkel N, Quantitative Proteomic Verification of Membrane Proteins as Potential Therapeutic Targets Located in the 11q13 Amplicon in Cancers. J Proteome Res, 14(9):3670-9(2015) [pubmed]

ProteomeXchange project tag: Chromosome-centric Human Proteome Project (C-HPP), Human Proteome Project

curator keyword: Biomedical

submitter keyword: Human, 11q13, head and neck, breast, OSCC, liver, LC-MSMS, TMT6 quantitation, cell surface protein enrichment

Nancy Finkel
contact affiliation	Novartis Isntitutes for Biomedical Research, Cambridge, MA 02139, USA DMP
contact email	nancy.finkel@novartis.com
lab head
Heather Hoover
contact affiliation	Novartis
contact email	heather.hoover@novartis.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/08/PXD002486

PRIDE project URI

• PRIDE
  1. PXD002486
     1. Label: PRIDE project
     2. Name: Target identification for 11q13 amplicon