PXD002468 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteomic analysis of salivary glands of female Aedes aegypti Linn |
Description | Aedes aegypti is a major vector for dengue, chikungunya and yellow fever. Though salivary gland plays a crucial role in transmission of virus and vector life cycle, there is no global and unbiased published report on salivary gland proteome of Ae. aegypti. In this study, we have carried out mass spectrometry based proteomic analysis of salivary gland from adult female Ae. aegypti mosquitoes. By fractionating the proteins isolated from salivary gland on SDS-PAGE and analyzing the in-gel digested bands on high resolution mass spectrometry, we identified 1,205 proteins. This is by far the largest catalogue of salivary gland proteome of Ae. aegypti. These proteins were then assigned molecular functions and biological processes. Several immunity related pathways were found to be enriched in salivary gland. In addition, subset of proteins was predicted to secretory in nature and may play an important role during blood feeding. This study provides a useful resource of proteins expressed in salivary gland of Ae. aegypti female mosquitoes and will aid in biomedical research focused on development of transmission blocking vaccine. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_08:48:41.373.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Rakhi Dhawan |
SpeciesList | scientific name: Aedes aegypti aegypti; NCBI TaxID: 1424507; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-07-02 00:56:28 | ID requested | |
1 | 2017-02-28 09:47:04 | announced | |
⏵ 2 | 2023-11-14 08:48:41 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: Hypothetical proteins, Saliva,LTQ-Velos mass spectrometer |
Contact List
Ashwani Kumar |
contact affiliation | National Institute of Malaria Research, Field Station, Goa 403001, India |
contact email | ashwani07@gmail.com |
lab head | |
Rakhi Dhawan |
contact affiliation | Dept of Community Medicine, Armed Forces Medical College, Pune |
contact email | rakhidhawan2012@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002468
- Label: PRIDE project
- Name: Proteomic analysis of salivary glands of female Aedes aegypti Linn