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PXD002468

PXD002468 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of salivary glands of female Aedes aegypti Linn
DescriptionAedes aegypti is a major vector for dengue, chikungunya and yellow fever. Though salivary gland plays a crucial role in transmission of virus and vector life cycle, there is no global and unbiased published report on salivary gland proteome of Ae. aegypti. In this study, we have carried out mass spectrometry based proteomic analysis of salivary gland from adult female Ae. aegypti mosquitoes. By fractionating the proteins isolated from salivary gland on SDS-PAGE and analyzing the in-gel digested bands on high resolution mass spectrometry, we identified 1,205 proteins. This is by far the largest catalogue of salivary gland proteome of Ae. aegypti. These proteins were then assigned molecular functions and biological processes. Several immunity related pathways were found to be enriched in salivary gland. In addition, subset of proteins was predicted to secretory in nature and may play an important role during blood feeding. This study provides a useful resource of proteins expressed in salivary gland of Ae. aegypti female mosquitoes and will aid in biomedical research focused on development of transmission blocking vaccine.
HostingRepositoryPRIDE
AnnounceDate2023-11-14
AnnouncementXMLSubmission_2023-11-14_08:48:41.373.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRakhi Dhawan
SpeciesList scientific name: Aedes aegypti aegypti; NCBI TaxID: 1424507;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-07-02 00:56:28ID requested
12017-02-28 09:47:04announced
22023-11-14 08:48:41announced2023-11-14: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: Hypothetical proteins, Saliva,LTQ-Velos mass spectrometer
Contact List
Ashwani Kumar
contact affiliationNational Institute of Malaria Research, Field Station, Goa 403001, India
contact emailashwani07@gmail.com
lab head
Rakhi Dhawan
contact affiliationDept of Community Medicine, Armed Forces Medical College, Pune
contact emailrakhidhawan2012@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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