PXD002468

PXD002468 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of salivary glands of female Aedes aegypti Linn
Description	Aedes aegypti is a major vector for dengue, chikungunya and yellow fever. Though salivary gland plays a crucial role in transmission of virus and vector life cycle, there is no global and unbiased published report on salivary gland proteome of Ae. aegypti. In this study, we have carried out mass spectrometry based proteomic analysis of salivary gland from adult female Ae. aegypti mosquitoes. By fractionating the proteins isolated from salivary gland on SDS-PAGE and analyzing the in-gel digested bands on high resolution mass spectrometry, we identified 1,205 proteins. This is by far the largest catalogue of salivary gland proteome of Ae. aegypti. These proteins were then assigned molecular functions and biological processes. Several immunity related pathways were found to be enriched in salivary gland. In addition, subset of proteins was predicted to secretory in nature and may play an important role during blood feeding. This study provides a useful resource of proteins expressed in salivary gland of Ae. aegypti female mosquitoes and will aid in biomedical research focused on development of transmission blocking vaccine.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:48:41.373.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rakhi Dhawan
SpeciesList	scientific name: Aedes aegypti aegypti; NCBI TaxID: 1424507;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-07-02 00:56:28	ID requested
1	2017-02-28 09:47:04	announced
⏵ 2	2023-11-14 08:48:41	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Hypothetical proteins, Saliva,LTQ-Velos mass spectrometer

Ashwani Kumar
contact affiliation	National Institute of Malaria Research, Field Station, Goa 403001, India
contact email	ashwani07@gmail.com
lab head
Rakhi Dhawan
contact affiliation	Dept of Community Medicine, Armed Forces Medical College, Pune
contact email	rakhidhawan2012@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2017/02/PXD002468

PRIDE project URI

• PRIDE
  1. PXD002468
     1. Label: PRIDE project
     2. Name: Proteomic analysis of salivary glands of female Aedes aegypti Linn