PXD002467 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats |
Description | Aging is associated with the decline of protein, cell, and organ function. Here, we use an integrated approach to characterize gene expression, bulk translation, and cell biology in the brains and livers of young and old rats. We identify 468 differences in protein abundance between young and old animals. The majority are a consequence of altered translation output, that is, the combined effect of changes in transcript abundance and translation efficiency. In addition, we identify 130 proteins whose overall abundance remains unchanged but whose sub-cellular localization, phosphorylation state, or splice-form varies. While some protein-level differences appear to be a generic property of the rats’ chronological age, the majority are specific to one organ. These may be a consequence of the organ’s physiology or the chronological age of the cells within the tissue. Taken together, our study provides an initial view of the proteome at the molecular, sub-cellular, and organ level in young and old rats. The corresponding dataset in Gene Expression Omnibus is GSE66715. |
HostingRepository | PRIDE |
AnnounceDate | 2017-10-24 |
AnnouncementXML | Submission_2017-10-24_05:54:07.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alessandro Ori |
SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116; |
ModificationList | phosphorylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-07-02 00:48:47 | ID requested | |
1 | 2015-10-05 03:47:14 | announced | |
2 | 2016-05-03 01:18:39 | announced | Updated publication reference for PubMed record(s): 27135913. |
3 | 2016-05-03 01:42:08 | announced | Updated project metadata. |
4 | 2017-06-20 05:43:40 | announced | Updated project metadata. |
⏵ 5 | 2017-10-24 05:54:08 | announced | Updated project metadata. |
Publication List
Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M, Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats. Cell Syst, 1(3):224-37(2015) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: aging, brain, liver, rat |
Contact List
Martin Beck |
contact affiliation | European Molecular Biology Laboratory |
contact email | martin.beck@embl.de |
lab head | |
Alessandro Ori |
contact affiliation | EMBL |
contact email | aleori@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/10/PXD002467 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002467
- Label: PRIDE project
- Name: Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats