PXD002454

PXD002454 is an original dataset announced via ProteomeXchange.

Title	Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection
Description	Enterovirus 71 (EV71) is one of the leading causes of hand, foot and mouth disease with neurological complications in some cases. To study the pathogenesis of EV71 infection, large scale analyses of EV71 infected cells have been performed. However, most of these studies employed rhabdomyosarcoma (RD) cells or used transcriptomic strategy. Here, we performed SILAC-based quantitative proteomic analysis of EV71-infected U251 cells, a human glioma cell line. A total of 3,125 host proteins were quantified, 451 of which were differentially regulated as a result of EV71 infection at 8 hpi or 20 hpi or both.
HostingRepository	PRIDE
AnnounceDate	2015-09-15
AnnouncementXML	Submission_2015-09-15_05:17:24.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lei-Ke Zhang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue; phosphorylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-30 23:47:23	ID requested
⏵ 1	2015-09-15 05:17:25	announced

Zhang LK, Lin T, Zhu SL, Xianyu LZ, Lu SY, Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection. Proteomics, 15(22):3784-96(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: EV71, SILAC, quantitative proteomics, TRAF2, TRAF6

Lei-Ke Zhang
contact affiliation	Wuhan Institute of Virology, Chinese Academy of Sciences
contact email	zhangleike@whu.edu.cn
lab head
Lei-Ke Zhang
contact affiliation	Wuhan Institute of Virology, Chinese Academy of Sciences
contact email	zhangleike@whu.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/09/PXD002454

PRIDE project URI

• PRIDE
  1. PXD002454
     1. Label: PRIDE project
     2. Name: Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection