PXD002453

PXD002453 is an original dataset announced via ProteomeXchange.

Title	Finding missing proteins from the epigenetically manipulated human cell with stringent quality criteria
Description	There are three major epigenetic mechanisms, DNA methylation, histone modifications, and ncRNAs. The histone is a key player in epigenetics, and the acetylation and methylation are their most common post-translational modifications (PTMs). These histone modifications have important roles in transcriptional regulation, DNA repair, DNA replication, alternative splicing and chromosome condensation. For example, we previously found that H3.3 lysine 36 trimethylation (H3.3K36me3) histone and its reader protein BS69 could work together to regulate pre-mRNA process. Therefore, in this study, we established in vitro histone acetylation, demethylation and methylation models, respectively, by using human lung, liver and colorectal cancer cells.
HostingRepository	PRIDE
AnnounceDate	2022-03-02
AnnouncementXML	Submission_2022-03-02_02:59:04.858.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xinlei Lian
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-30 04:57:10	ID requested
⏵ 1	2022-03-02 02:59:05	announced

Yang L, Lian X, Zhang W, Guo J, Wang Q, Li Y, Chen Y, Yin X, Yang P, Lan F, He QY, Zhang G, Wang T, Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria. J Proteome Res, 14(9):3645-57(2015) [pubmed]

ProteomeXchange project tag: Chromosome-centric Human Proteome Project (C-HPP), Human Proteome Project

curator keyword: Biological

submitter keyword: Chromosome-Centric Human Proteome Project, epigenetic, histone, missing proteins

He Qing-Yu
contact affiliation	Institute of Life and Health Engineering Assistant Director, Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Jinan University
contact email	tqyhe@email.jnu.edu.cn
lab head
Xinlei Lian
contact affiliation	+8613719403020
contact email	lian19890207@126.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD002453

PRIDE project URI

• PRIDE
  1. PXD002453
     1. Label: PRIDE project
     2. Name: Finding missing proteins from the epigenetically manipulated human cell with stringent quality criteria