PXD002432 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Reproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans |
Description | We identify changes in the C. elegans proteome that occur with increased age. We find that secreted proteins and proteins specifically expressed in adult animals tend to increase in abundance with age. A subset of these proteins is solely expressed in the extracellular space of the adult uterus. These uterine protiens are rapidly turned over in yound adult animals, but are removed much more slowly in old worms. The dataset presented here describes the quantification of protein abundance in young and old adult worms as measured by LC-MS/MS. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:05:52.357.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Izumi Hinkson |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | monohydroxylated residue; iodoacetamide derivatized residue; N6,N6-dimethyl-L-lysine |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-06-29 01:12:12 | ID requested | |
1 | 2018-10-24 10:02:41 | announced | |
⏵ 2 | 2024-10-22 04:06:00 | announced | 2024-10-22: Updated project metadata. |
Publication List
10.1371/journal.pgen.1005725; |
Zimmerman SM, Hinkson IV, Elias JE, Kim SK, Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans. PLoS Genet, 11(12):e1005725(2015) [pubmed] |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: C. elegans, proteomics, mass spectrometry, aging |
Contact List
Josh Elias |
contact affiliation | Stanford University Department of Chemical and Systems Biology |
contact email | josh.elias@stanford.edu |
lab head | |
Izumi Hinkson |
contact affiliation | Stanford University |
contact email | ivhinkson@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD002432 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002432
- Label: PRIDE project
- Name: Reproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans