PXD002432

PXD002432 is an original dataset announced via ProteomeXchange.

Title	Reproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans
Description	We identify changes in the C. elegans proteome that occur with increased age. We find that secreted proteins and proteins specifically expressed in adult animals tend to increase in abundance with age. A subset of these proteins is solely expressed in the extracellular space of the adult uterus. These uterine protiens are rapidly turned over in yound adult animals, but are removed much more slowly in old worms. The dataset presented here describes the quantification of protein abundance in young and old adult worms as measured by LC-MS/MS.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:05:52.357.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Izumi Hinkson
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; N6,N6-dimethyl-L-lysine
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-29 01:12:12	ID requested
1	2018-10-24 10:02:41	announced
⏵ 2	2024-10-22 04:06:00	announced	2024-10-22: Updated project metadata.

10.1371/journal.pgen.1005725;

Zimmerman SM, Hinkson IV, Elias JE, Kim SK, Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans. PLoS Genet, 11(12):e1005725(2015) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: C. elegans, proteomics, mass spectrometry, aging

Josh Elias
contact affiliation	Stanford University Department of Chemical and Systems Biology
contact email	josh.elias@stanford.edu
lab head
Izumi Hinkson
contact affiliation	Stanford University
contact email	ivhinkson@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD002432

PRIDE project URI

• PRIDE
  1. PXD002432
     1. Label: PRIDE project
     2. Name: Reproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans