⮝ Full datasets listing

PXD002432

PXD002432 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleReproductive aging drives protein accumulation in the uterus and limits lifespan in C. elegans
DescriptionWe identify changes in the C. elegans proteome that occur with increased age. We find that secreted proteins and proteins specifically expressed in adult animals tend to increase in abundance with age. A subset of these proteins is solely expressed in the extracellular space of the adult uterus. These uterine protiens are rapidly turned over in yound adult animals, but are removed much more slowly in old worms. The dataset presented here describes the quantification of protein abundance in young and old adult worms as measured by LC-MS/MS.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:05:52.357.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterIzumi Hinkson
SpeciesList scientific name: Caenorhabditis elegans; NCBI TaxID: 6239;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue; N6,N6-dimethyl-L-lysine
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-06-29 01:12:12ID requested
12018-10-24 10:02:41announced
22024-10-22 04:06:00announced2024-10-22: Updated project metadata.
Publication List
10.1371/journal.pgen.1005725;
Zimmerman SM, Hinkson IV, Elias JE, Kim SK, Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans. PLoS Genet, 11(12):e1005725(2015) [pubmed]
Keyword List
curator keyword: Biological, Biomedical
submitter keyword: C. elegans, proteomics, mass spectrometry, aging
Contact List
Josh Elias
contact affiliationStanford University Department of Chemical and Systems Biology
contact emailjosh.elias@stanford.edu
lab head
Izumi Hinkson
contact affiliationStanford University
contact emailivhinkson@gmail.com
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/10/PXD002432
PRIDE project URI
Repository Record List
[ + ]