PXD002342

PXD002342 is an original dataset announced via ProteomeXchange.

Title	The dynamic regulatory genome of Capsaspora owczarzaki and the origin of animal multicellularity
Description	Recent evidence that the unicellular ancestor of animals had a complex repertoire of genes linked to multicellular processes suggests that changes in the regulatory genome, rather than gene innovation, were key to the origin of animals. Here, we carry out multiple functional genomic assays in Capsaspora owczarzaki, the unicellular relative of animals with the largest known gene repertoire for transcriptional regulation. We show that changing chromatin states, differential lincRNA expression and dynamic cis-regulatory sites are associated with life cycle transitions in Capsaspora. Moreover, we demonstrate conservation of animal developmental transcription factor networks and extensive network interconnection in this premetazoan organism. In contrast, however, Capsaspora lacks animal promoter types and its regulatory sites are small, proximal and lack signatures of animal enhancers. Overall, our results indicate that the emergence of animal multicellularity was linked to a major shift in genome regulatory complexity, most notably the appearance of distal enhancer regulation.
HostingRepository	PRIDE
AnnounceDate	2018-10-24
AnnouncementXML	Submission_2018-10-24_09:49:13.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Cristina Chiva
SpeciesList	scientific name: Capsaspora owczarzaki; NCBI TaxID: 192875;
ModificationList	methylated residue; trimethylated residue; acetylated residue; dimethylated residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-10 02:19:25	ID requested
⏵ 1	2018-10-24 09:49:15	announced

Seb, é, -Pedr, ó, s A, Ballar, é C, Parra-Acero H, Chiva C, Tena JJ, Sabid, ó E, G, ó, mez-Skarmeta JL, Di Croce L, Ruiz-Trillo I, The Dynamic Regulatory Genome of Capsaspora and the Origin of Animal Multicellularity. Cell, 165(5):1224-1237(2016) [pubmed]

curator keyword: Biological

submitter keyword: Histone acetylation methylation dimethilation trimethylation Capsaspora owczarzaki

Iñaki Ruiz
contact affiliation	Institut de Biologia Evolutiva, IBE
contact email	inaki.ruiz@ibe.upf-csic.es
lab head
Cristina Chiva
contact affiliation	Center of genomic regulation
contact email	chiva.cristina@gmail.com
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD002342
     1. Label: PRIDE project
     2. Name: The dynamic regulatory genome of Capsaspora owczarzaki and the origin of animal multicellularity