PXD002318

PXD002318 is an original dataset announced via ProteomeXchange.

Title	Multiple sclerosis resaerch: EAE and cuprizone mouse brain TMT and label-free proteomics
Description	Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, and in this study we used quantitative proteomics to compare the brain proteomes of two MS mouse models, the immune-mediated experimental autoimmune encephalomyelitis (acute and recovery phase) and cuprizone (late de-/remyelination) with that of corresponding control mice. Proteomics using LC-MS with TMT-labeling and label-free quantification resulted in the quantification of 3664 and 2582 proteins (including protein groups), respectively, a total of 4375 different proteins. Differences between the disease model mice and the controls were revealed and protein candidates were discovered and translated to human disease.
HostingRepository	PRIDE
AnnounceDate	2021-03-16
AnnouncementXML	Submission_2021-03-16_06:20:12.969.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Eystein Oveland
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-08 02:05:08	ID requested
⏵ 1	2021-03-16 06:20:13	announced

Dataset with its publication pending

curator keyword: Biomedical

submitter keyword: Mus musculus, brain, TMT, label-free, Orbitrap Velos

Frode S. Berven
contact affiliation	Proteomics Unit at University of Bergen
contact email	frode.berven@uib.no
lab head
Eystein Oveland
contact affiliation	University of Bergen
contact email	eystein.oveland@biomed.uib.no
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/03/PXD002318

PRIDE project URI

• PRIDE
  1. PXD002318
     1. Label: PRIDE project
     2. Name: Multiple sclerosis resaerch: EAE and cuprizone mouse brain TMT and label-free proteomics