PXD002269

PXD002269 is an original dataset announced via ProteomeXchange.

Title	ER stress response in hepatocytes upon Plasmodium infection
Description	Upon infection of a mammalian host, Plasmodium parasites first replicate inside hepato-cytes, generating thousands of new parasites. Although Plasmodium intra-hepatic devel-opment represents a substantial metabolic challenge to the host hepatocyte, how infected cells respond to and integrate this stress remains poorly understood. Here, we present proteomic and transcriptomic analysis revealing that the endoplasmic reticulum (ER)-resident unfolded protein response (UPR) is activated in host hepatocytes upon Plasmo-dium berghei infection. The expression of XBP1s -the active form of the UPR mediator XBP1- and the liver-specific UPR mediator CREBH is induced by P. berghei infection in vivo. Furthermore, this UPR induction increases parasite liver burden. Altogether, our data suggests that ER stress is a central feature of P. berghei intra-hepatic development, contributing to the success of infection.
HostingRepository	PRIDE
AnnounceDate	2016-04-20
AnnouncementXML	Submission_2016-04-20_09:53:32.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nagarjuna Nagaraj
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-05-31 23:39:13	ID requested
⏵ 1	2016-04-20 09:53:33	announced

In, á, cio P, Zuzarte-Lu, í, s V, Ruivo MT, Falkard B, Nagaraj N, Rooijers K, Mann M, Mair G, Fidock DA, Mota MM, Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection. EMBO Rep, 16(8):955-64(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: HuH7 plasmodium infection

Maria Manuel Dias Mota
contact affiliation	Executive Director Instituto de Medicina Molecular Av. Prof. Egas Moniz 1649-028 Lisboa, Portugal Tel: (+351) 217 999 511
contact email	mmota@medicina.ulisboa.pt
lab head
Nagarjuna Nagaraj
contact affiliation	MaxPlanck Institute for Biochemistry, Core facility
contact email	nagaraj@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/04/PXD002269

PRIDE project URI

• PRIDE
  1. PXD002269
     1. Label: PRIDE project
     2. Name: ER stress response in hepatocytes upon Plasmodium infection