PXD002252

PXD002252 is an original dataset announced via ProteomeXchange.

Title	Identification and characterization of DNA sequences that restrict genomic binding of the glucocorticoid receptor
Description	The glucocorticoid receptor (GR), is a hormone-activated transcription factor which binds to GR binding sequences (GBS) encoded in the genome. Interestingly, of the many genomic sequences matching the GR consensus sequence only a small subset is actually bound. This indicates that the presence of a GBS alone is insufficient to specify where in the genome GR binds. We identified sequences that can locally prevent GR binding and mass-spec analysis was used to identify proteins that bind to these sequences.
HostingRepository	PRIDE
AnnounceDate	2016-03-31
AnnouncementXML	Submission_2016-03-31_05:36:29.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	David Meierhofer
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-05-29 02:41:13	ID requested
⏵ 1	2016-03-31 05:36:31	announced

Telorac J, Prykhozhij SV, Sch, ö, ne S, Meierhofer D, Sauer S, Thomas-Chollier M, Meijsing SH, Identification and characterization of DNA sequences that prevent glucocorticoid receptor binding to nearby response elements. Nucleic Acids Res, 44(13):6142-56(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: glucocorticoid receptor, negative regulatory sequences, dna binding

Sebastiaan H. Meijsing
contact affiliation	MPIMG
contact email	meijsing@molgen.mpg.de
lab head
David Meierhofer
contact affiliation	MPIMG
contact email	Meierhof@molgen.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/03/PXD002252

PRIDE project URI

• PRIDE
  1. PXD002252
     1. Label: PRIDE project
     2. Name: Identification and characterization of DNA sequences that restrict genomic binding of the glucocorticoid receptor