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PXD002233

PXD002233 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleKSR1 and genotoxic agents in MCF7 (SILAC-MS)
DescriptionWe use KSR1 overexpression and exposure to doxorubin or etoposide in MCF7 cells to reveal a comprehensive repertoire of thousands of proteins identified in each dataset and compare the unique proteomic profile as well as functional connections modulated by KSR1 after doxorubicin (Doxo-KSR1) or etoposide (Etop-KSR1) stimulus. From the up-regulated top hits, several proteins, including STAT1, ISG15 and TAP1 were also found to be positively associated with KSR1 expression in patient samples. Moreover, high KSR1 expression, as well as high abundance of these proteins, is correlated with better survival in breast cancer patients who underwent chemotherapy. Our data exemplify a broad functional network conferred by KSR1 with genotoxic agents and highlight its implication in predicting chemotherapy response in breast cancer.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:35:01.291.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterGeorgios Giamas
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentLTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-05-26 06:38:07ID requested
12022-03-02 06:55:47announced
22024-10-22 05:35:01announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
curator keyword: Biomedical
submitter keyword: doxorubicin, KSR1, Breast Cancer,SILAC, etoposide
Contact List
Georgios Giamas
contact affiliationImperial College, London
contact emailg.giamas@imperial.ac.uk
lab head
Georgios Giamas
contact affiliationImperial College
contact emailg.giamas@imperial.ac.uk
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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