PXD002233 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | KSR1 and genotoxic agents in MCF7 (SILAC-MS) |
Description | We use KSR1 overexpression and exposure to doxorubin or etoposide in MCF7 cells to reveal a comprehensive repertoire of thousands of proteins identified in each dataset and compare the unique proteomic profile as well as functional connections modulated by KSR1 after doxorubicin (Doxo-KSR1) or etoposide (Etop-KSR1) stimulus. From the up-regulated top hits, several proteins, including STAT1, ISG15 and TAP1 were also found to be positively associated with KSR1 expression in patient samples. Moreover, high KSR1 expression, as well as high abundance of these proteins, is correlated with better survival in breast cancer patients who underwent chemotherapy. Our data exemplify a broad functional network conferred by KSR1 with genotoxic agents and highlight its implication in predicting chemotherapy response in breast cancer. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:35:01.291.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Georgios Giamas |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-05-26 06:38:07 | ID requested | |
1 | 2022-03-02 06:55:47 | announced | |
⏵ 2 | 2024-10-22 05:35:01 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: doxorubicin, KSR1, Breast Cancer,SILAC, etoposide |
Contact List
Georgios Giamas |
contact affiliation | Imperial College, London |
contact email | g.giamas@imperial.ac.uk |
lab head | |
Georgios Giamas |
contact affiliation | Imperial College |
contact email | g.giamas@imperial.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/03/PXD002233 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002233
- Label: PRIDE project
- Name: KSR1 and genotoxic agents in MCF7 (SILAC-MS)