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PXD002213

PXD002213 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGastric cancer ascites proteome
DescriptionGastric cancer is one of the most lethal malignancies with high mortality and gastric cancer-specific biomarker is need due to the lack of specific method for early screening, diagnosis, and prognosis of the patients with gastric cancer. Ascites is known for an important source for conducing biomarker discovery because it contains the secreted proteins from malignant cells, growth factors, and cytokines. In this study, we have conducted a comprehensive proteome study using ascites of patients with inflammatory diseases and gastric cancer. In the discovery stage, we have identified 2761 ascites-specific proteins, where 234 proteins were quantitated using the label free quantitation method, the normalized spectral abundance factor (NSAF); 152 and 82 proteins showed up and down-regulated pattern, respectively. Our ascites proteome can be used as baseline data for the discovery of novel biomarkers of the gastric cancer.
HostingRepositoryPRIDE
AnnounceDate2018-04-16
AnnouncementXMLSubmission_2018-04-16_02:53:16.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterDohyun Han
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-05-20 06:34:04ID requested
12018-04-16 02:53:17announced
Publication List
Jin J, Son M, Kim H, Kim H, Kong SH, Kim HK, Kim Y, Han D, Comparative proteomic analysis of human malignant ascitic fluids for the development of gastric cancer biomarkers. Clin Biochem, 56():55-61(2018) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Gastric cancer, Ascites, biomarker, proteomics, proteome profiling
Contact List
Dohyun Han
contact affiliationProteomics core facility, Seoul National University Hospital
contact emailhdh03@snu.ac.kr
lab head
Dohyun Han
contact affiliationColleage of medicine
contact emailhdh03@snu.ac.kr
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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