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DataSet Summary

  • HostingRepository: PRIDE
  • AnnounceDate: 2018-04-16
  • AnnouncementXML: Submission_2018-04-16_02:53:16.xml
  • DigitalObjectIdentifier:
  • ReviewLevel: Peer-reviewed dataset
  • DatasetOrigin: Original data
  • RepositorySupport: Unsupported dataset by repository
  • PrimarySubmitter: Dohyun Han
  • Title: Gastric cancer ascites proteome
  • Description: Gastric cancer is one of the most lethal malignancies with high mortality and gastric cancer-specific biomarker is need due to the lack of specific method for early screening, diagnosis, and prognosis of the patients with gastric cancer. Ascites is known for an important source for conducing biomarker discovery because it contains the secreted proteins from malignant cells, growth factors, and cytokines. In this study, we have conducted a comprehensive proteome study using ascites of patients with inflammatory diseases and gastric cancer. In the discovery stage, we have identified 2761 ascites-specific proteins, where 234 proteins were quantitated using the label free quantitation method, the normalized spectral abundance factor (NSAF); 152 and 82 proteins showed up and down-regulated pattern, respectively. Our ascites proteome can be used as baseline data for the discovery of novel biomarkers of the gastric cancer.
  • SpeciesList: scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
  • ModificationList: monohydroxylated residue; iodoacetamide derivatized residue
  • Instrument: Q Exactive

Dataset History

VersionDatetimeStatusChangeLog Entry
02015-05-20 06:34:04ID requested
12018-04-16 02:53:17announced

Publication List

  1. Jin J, Son M, Kim H, Kim H, Kong SH, Kim HK, Kim Y, Han D, Comparative proteomic analysis of human malignant ascitic fluids for the development of gastric cancer biomarkers. Clin Biochem, 56():55-61(2018) [pubmed]

Keyword List

  1. curator keyword: Biomedical
  2. submitter keyword: Gastric cancer, Ascites, biomarker, proteomics, proteome profiling

Contact List

    Dohyun Han
    • contact affiliation: Proteomics core facility, Seoul National University Hospital
    • contact email: hdh03@snu.ac.kr
    • lab head:
    Dohyun Han
    • contact affiliation: Colleage of medicine
    • contact email: hdh03@snu.ac.kr
    • dataset submitter:

Full Dataset Link List

  1. Dataset FTP location
  2. PRIDE project URI
Repository Record List
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