PXD002185 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Schistosoma japonicum cercaria and schistosomula |
Description | Schistosomiasis is a parasitic zoonosis which caused by schistosomes and poses great threat to the health of human and other mammals. Schistosome cercaria must penetrate skin as an initial step to successfully infect the final host. Proteolytic enzymes secreted from the acetabular glands of cercaria contribute significantly to the invasion process. In this study, we designed a new cercaria transformation experiment to get the penetrated cercaria (schistosomula), then a gel-free shotgun proteomic analysis were performed to compare the proteomes of cercaria and schistosomula. 1894 and 1002 proteins were identified respectively, 924 proteins were common in both of two samples, almost take up 92% of the total proteins of schistosomula. The identified proteins were closely associated with nine main biological processes through Gene Ontology (GO) categorical analysis. The identification of the proteins potentially related to skin penetration offer a global overview of changes during cercaria skin invasion, providing clues into how they involve in the penetration process. Various proteases and peptidases were detected, and were differentially existed before and after cercaria transformation, suggesting proteases-specific roles and complexity mechanism during invasion. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:24:44.544.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Mu Liu |
SpeciesList | scientific name: Caenorhabditis elegans; NCBI TaxID: 6239; |
ModificationList | monohydroxylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-05-14 02:14:20 | ID requested | |
1 | 2017-05-08 02:10:42 | announced | |
⏵ 2 | 2024-10-22 04:24:45 | announced | 2024-10-22: Updated project metadata. |
Publication List
Liu M, Ju C, Du XF, Shen HM, Wang JP, Li J, Zhang XM, Feng Z, Hu W, Proteomic Analysis on Cercariae and Schistosomula in Reference to Potential Proteases Involved in Host Invasion of Schistosoma japonicum Larvae. J Proteome Res, 14(11):4623-34(2015) [pubmed] |
10.1021/acs.jproteome.5b00465; |
Keyword List
curator keyword: Biological, Biomedical |
submitter keyword: schistosomula, cercaria, proteome,schistosoma japonicum |
Contact List
Mu Liu |
contact affiliation | Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China |
contact email | lovemotherchina@163.com |
lab head | |
Mu Liu |
contact affiliation | Fudan university |
contact email | lovemotherchina@163.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD002185
- Label: PRIDE project
- Name: Schistosoma japonicum cercaria and schistosomula