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PXD002135

PXD002135 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DescriptionDNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. However, the ATR-dependent signaling in the cellular response to replication stress has not been systematically investigated. Here, we employ quantitative mass spectrometry-based proteomics to decipher the ATR-dependent phosphorylation events in response to pathological replication stress induced by hydroxyurea. Our data define the substrate spectrum of ATR and identify several novel putative ATR substrates. In addition, we demonstrate that ATR-inhibition fundamentally rewires cellular signaling networks leading to the prominent activation of different pathways including the ATM-driven double strand break repair.
HostingRepositoryPRIDE
AnnounceDate2015-11-24
AnnouncementXMLSubmission_2015-11-24_00:16:24.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterPetra Beli
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListphosphorylated residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-05-01 08:26:36ID requested
12015-11-24 00:16:25announced
Publication List
Wagner SA, Oehler H, Voigt A, Dalic D, Freiwald A, Serve H, Beli P, ATR inhibition rewires cellular signaling networks induced by replication stress. Proteomics, 16(3):402-16(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Phosphorytion, ATR, Phosphoproteomics
Contact List
Petra Beli
contact affiliationInstitute of Molecular Biology (IMB), Mainz, Germany
contact emailp.beli@imb-mainz.de
lab head
Petra Beli
contact affiliationInstitute of Molecular Biology (IMB), Mainz, Germany
contact emailp.beli@imb-mainz.de
dataset submitter
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Dataset FTP location
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PRIDE project URI
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