PXD002058

PXD002058 is an original dataset announced via ProteomeXchange.

Title	Tau interactome
Description	The tau protein is central to the etiology of several neurodegenerative diseases, including Alzheimer’s disease, a subset of frontotemporal dementias, progressive supranuclear palsy and dementia following traumatic brain injury, yet the proteins it interacts with have not been studied using a systematic discovery approach. The study employed mild in vivo crosslinking, isobaric labeling and tandem mass spectrometry to characterize molecular interactions of human tau in a neuroblastoma cell model.
HostingRepository	PRIDE
AnnounceDate	2015-08-17
AnnouncementXML	Submission_2015-08-24_08:01:11.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gerold Schmitt-Ulms
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	deamidated residue; S-pyridylethyl-L-cysteine; iTRAQ4plex-116 reporter+balance reagent acylated residue; carbamoylated residue; TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion ETD

Revision	Datetime	Status	ChangeLog Entry
0	2015-04-13 02:31:20	ID requested
1	2015-08-17 02:53:26	announced
⏵ 2	2015-08-24 08:01:12	announced	Updated publication reference for PubMed record(s): 26269332.

Gunawardana CG, Mehrabian M, Wang X, Mueller I, Lubambo IB, Jonkman JE, Wang H, Schmitt-Ulms G, The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome. Mol Cell Proteomics, 14(11):3000-14(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: tau, human, interactome, mass spectrometry, alzheimer, frontotemporal dementia

Gerold Schmitt-Ulms
contact affiliation	Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario M5T2S8, Canada. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S1A8, Canada
contact email	g.schmittulms@utoronto.ca
lab head
Gerold Schmitt-Ulms
contact affiliation	University of Toronto
contact email	g.schmittulms@utoronto.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/08/PXD002058

PRIDE project URI

• PRIDE
  1. PXD002058
     1. Label: PRIDE project
     2. Name: Tau interactome