PXD002057

PXD002057 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis identifies novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy
Description	Resistance to Human Epidermal Growth Factor Receptor (HER)-targeted cancer therapies appear to be occurring via common pathways, despite differences in their mechanism of action. This suggests that combination therapies targeting alternative pathways will be needed to overcome resistance. We have used a global proteomics approach to identify common signaling nodes that are required for driving HER2-independent resistance mechanisms to the pan-HER family kinase inhibitors AZD8931 and lapatinib. A novel set of epithelial–to-mesenchymal transition (EMT) associated proteins linked to resistance to pan-HER family targeted therapy was identified. We demonstrate that a sub-set of these genes are predictive of prognosis within the ERBB2 subtype of breast cancers and are worthy of further study in the context of preventing resistance to anti-HER family agents. Furthermore, targeting these pathways, perhaps via combination with galectin-1 or Axl inhibitors may provide additional strategies for the treatment of resistant tumours.
HostingRepository	PRIDE
AnnounceDate	2016-02-22
AnnouncementXML	Submission_2016-02-22_02:13:26.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002057
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Thierry Le Bihan
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue; phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-04-13 02:22:08	ID requested
⏵ 1	2016-02-22 02:13:27	announced

Creedon H, G, ó, mez-Cuadrado L, Tarnauskait, ė Ž, Balla J, Canel M, MacLeod KG, Serrels B, Fraser C, Unciti-Broceta A, Tracey N, Le Bihan T, Klinowska T, Sims AH, Byron A, Brunton VG, Identification of novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy. Oncotarget, 7(10):11539-52(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: acquired resistance, breast cancer, EMT, HER2, proteomics

Thierry Le Bihan
contact affiliation	SynthSys University of Edinburgh
contact email	thierry.lebihan@ed.ac.uk
lab head
Thierry Le Bihan
contact affiliation	Centre for Systems biology at edinburgh
contact email	thierry.lebihan@ed.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD002057

PRIDE project URI

• PRIDE
  1. PXD002057
     1. Label: PRIDE project
     2. Name: Proteomic analysis identifies novel pathways linking epithelial-to-mesenchymal transition with resistance to HER2-targeted therapy