PXD002039

PXD002039 is an original dataset announced via ProteomeXchange.

Title	Expression dynamics in mammalian cells responding to protein misfolding stress
Description	The relative importance of gene expression regulation at the mRNA versus the protein-level is a matter of ongoing debate. We present an in-depth analysis of a cervical cancer cell line responding to protein misfolding stress induced by dithiothreitol treatment, quantifying the dynamics of mRNA and protein concentrations for >3,500 genes over a time-course 30 hours. While the early phase of the experiment (
HostingRepository	PRIDE
AnnounceDate	2016-03-14
AnnouncementXML	Submission_2016-03-14_09:12:54.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhe Cheng
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-04-10 02:34:33	ID requested
⏵ 1	2016-03-14 09:12:55	announced

Cheng Z, Teo G, Krueger S, Rock TM, Koh HW, Choi H, Vogel C, Differential dynamics of the mammalian mRNA and protein expression response to misfolding stress. Mol Syst Biol, 12(1):855(2016) [pubmed]

submitter keyword: Human, HeLa, protein misfolding stress, LC-MSMS

Christine Vogel
contact affiliation	Center for Genomics and Systems Biology, New York University, New York, NY, US
contact email	cvogel@nyu.edu
lab head
Zhe Cheng
contact affiliation	New York University
contact email	zhecheng2010@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/03/PXD002039

PRIDE project URI

• PRIDE
  1. PXD002039
     1. Label: PRIDE project
     2. Name: Expression dynamics in mammalian cells responding to protein misfolding stress