PXD002006

PXD002006 is an original dataset announced via ProteomeXchange.

Title	Changes in proteome upon mTOR activation
Description	mTOR activation has been known to affect protein synthesis. To identify molecular signatures in transcriptome that could enhance protein synthesis, RNA-seq and quantitative proteomics studies were conducted using WT and TSC1 null MEFs. In this study, we found that the activation of mTOR leads to genome-wide 3'UTR shortening in mRNAs by alternative polyadenylation and activates ubiquitin-mediated proteolysis
HostingRepository	PRIDE
AnnounceDate	2015-06-16
AnnouncementXML	Submission_2015-06-16_12:15:28.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD002006
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ebbing de Jong
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	Oxidation; Acetyl; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-04-01 03:19:08	ID requested
⏵ 1	2015-06-16 12:15:29	announced

Chang JW, Zhang W, Yeh HS, de Jong EP, Jun S, Kim KH, Bae SS, Beckman K, Hwang TH, Kim KS, Kim DH, Griffin TJ, Kuang R, Yong J, mRNA 3'-UTR shortening is a molecular signature of mTORC1 activation. Nat Commun, 6():7218(2015) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: alternative polyadenylation, mTOR, 3'UTR shortening, ubiquitin-mediated proteolysis

Jeongsik Yong
contact affiliation	BMBB, University of Minnesota, USA
contact email	jyong@umn.edu
lab head
Ebbing de Jong
contact affiliation	University of Minnesota
contact email	ebbingdejong@umn.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD002006
     1. Label: PRIDE project
     2. Name: Changes in proteome upon mTOR activation