PXD001997

PXD001997 is an original dataset announced via ProteomeXchange.

Title	Protein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
Description	his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western blot against the mutated protein TGFBIp that cause the protein accumulation in the cornea, was examined and compared to normal corneal tissue.
HostingRepository	PRIDE
AnnounceDate	2016-02-19
AnnouncementXML	Submission_2016-02-19_08:04:25.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001997
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Ebbe Toftgaard Poulsen
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Met->Hsl; Oxidation; Carbamidomethyl; Met->Hse
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2015-03-30 07:03:44	ID requested
⏵ 1	2016-02-19 08:04:26	announced

Poulsen ET, Nielsen NS, Jensen MM, Nielsen E, Hjortdal J, Kim EK, Enghild JJ, LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp). Proteomics, 16(3):539-43(2016) [pubmed]

curator keyword: Biomedical

submitter keyword: Granular Corneal Dystrophy, Cornea, TripleTof 5600+, XIC quantification, 2D-PAGE

Jan Johannes Enghild
contact affiliation	Department of Molecular Biology and Genetics, Aarhus University, Denmark
contact email	jje@mbg.au.dk
lab head
Ebbe Toftgaard Poulsen
contact affiliation	Department of Molecular Biology and Genetics
contact email	etp@mb.au.dk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD001997
     1. Label: PRIDE project
     2. Name: Protein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)