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PXD001997

PXD001997 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProtein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)
Descriptionhis study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western blot against the mutated protein TGFBIp that cause the protein accumulation in the cornea, was examined and compared to normal corneal tissue.
HostingRepositoryPRIDE
AnnounceDate2016-02-19
AnnouncementXMLSubmission_2016-02-19_08:04:25.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD001997
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterEbbe Toftgaard Poulsen
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListMet->Hsl; Oxidation; Carbamidomethyl; Met->Hse
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-03-30 07:03:44ID requested
12016-02-19 08:04:26announced
Publication List
Poulsen ET, Nielsen NS, Jensen MM, Nielsen E, Hjortdal J, Kim EK, Enghild JJ, LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp). Proteomics, 16(3):539-43(2016) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Granular Corneal Dystrophy, Cornea, TripleTof 5600+, XIC quantification, 2D-PAGE
Contact List
Jan Johannes Enghild
contact affiliationDepartment of Molecular Biology and Genetics, Aarhus University, Denmark
contact emailjje@mbg.au.dk
lab head
Ebbe Toftgaard Poulsen
contact affiliationDepartment of Molecular Biology and Genetics
contact emailetp@mb.au.dk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
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