PXD001987 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | TMT-labeled quantitative protein profiling of hippocampus during human aging |
Description | Human hippocampus is one of the critical brain regions affected by aging. However, a fully understanding of aging-related changes in protein profiles in human hippocampus has not been well described, especially for the Chinese population. With the newly founded human brain bank in Chinese Academy of Medical Sciences & Peking Union Medical College, we performed a 4-plex TMT labeled proteomic study in the hippocampus of postmortem human brains. The ages of death ranged from 22-98, and were grouped into 4 aging groups: 20-50, 50-70, 70-90, and over 90 (n=4 each). None of the donors was diagnosed with neurodegenerative diseases according to their medical history. Our data identified 4582 proteins, among which 99 proteins were upregulated and 42 proteins were downregulated during the aging process. |
HostingRepository | PRIDE |
AnnounceDate | 2016-04-13 |
AnnouncementXML | Submission_2016-04-13_02:47:27.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Wei Ge |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | TMT6plex-126 reporter+balance reagent acylated residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-03-27 04:00:48 | ID requested | |
⏵ 1 | 2016-04-13 02:47:28 | announced | |
Publication List
Xu B, Gao Y, Zhan S, Xiong F, Qiu W, Qian X, Wang T, Wang N, Zhang D, Yang Q, Wang R, Bao X, Dou W, Tian R, Meng S, Gai WP, Huang Y, Yan XX, Ge W, Ma C, Quantitative protein profiling of hippocampus during human aging. Neurobiol Aging, 39():46-56(2016) [pubmed] |
Keyword List
curator keyword: Biomedical, Biological |
submitter keyword: Human, Aging, Hippocampus |
Contact List
Wei Ge |
contact affiliation | Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, National Key Laboratory of Medical Molecular Biology & Department of Immunology, No 5 Dongdan Santiao, Dongcheng district, Beijing 100005, China |
contact email | wei.ge@chem.ox.ac.uk |
lab head | |
Wei Ge |
contact affiliation | National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences |
contact email | wei.ge@chem.ox.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001987
- Label: PRIDE project
- Name: TMT-labeled quantitative protein profiling of hippocampus during human aging