PXD001973

PXD001973 is an original dataset announced via ProteomeXchange.

Title	Proteome Comparison of Different-Aged Cochlea
Description	Our work describes the application of mass spectrometry-based label-free quantitative proteomics for the identification of differentially expressed proteins between different-aged cochlea. We report proteins exclusively present as well as up- and downregulated in the cochlear sensory epithelium at significant developmental stages. Additionally, we report proteins exclusively present on P3 that were recently identified in the cochlea for the first time. We use bioinformatics to provide insight on biological functions and potential primary and secondary partners of the differentially expressed proteins. This study provides the first differentially expressed proteome in the mammalian cochlea at significant developmental stages; before hearing, during the onset of hearing, and when hearing is fully developed. We believe that these results will provide insights into the function of proteins that change during development and identify potential protein biomarkers related to hearing impairments.
HostingRepository	PRIDE
AnnounceDate	2018-08-29
AnnouncementXML	Submission_2018-08-29_03:06:08.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lancia Darville
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-03-25 01:39:20	ID requested
⏵ 1	2018-08-29 03:06:10	announced

Darville LNF, Sokolowski BHA, Label-free quantitative mass spectrometry analysis of differential protein expression in the developing cochlear sensory epithelium. Proteome Sci, 16():15(2018) [pubmed]

curator keyword: Biological

submitter keyword: cochlea, development, quantitative mass spectrometry, proteomics, sensory epithelium

Bernd Sokolowski
contact affiliation	University of South Florida Morsani College of Medicine Department of Otolaryngology 12901 Bruce B. Downs Blvd. Otology Laboratory MDC83 Tampa FL 33647
contact email	bsokolow@health.usf.edu
lab head
Lancia Darville
contact affiliation	University of South Florida
contact email	lancia.darville@hotmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/08/PXD001973

PRIDE project URI

• PRIDE
  1. PXD001973
     1. Label: PRIDE project
     2. Name: Proteome Comparison of Different-Aged Cochlea