PXD001952

PXD001952 is an original dataset announced via ProteomeXchange.

Title	Multi-omics approach to identify age-related changes in mesenchymal stem cells
Description	Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstrated to possess an age-related loss of cellular functions including differentiation potential and proliferation capacity; with implications for stem cell therapies in older patients. Furthermore the reduction in differentiation potential could contribute to ageing and age-related disease. Biological aging is coupled with a progressive reduction in the regulation of cellular, tissue and organ interaction, resulting in senescence. The purpose of this study was to investigate the epigenetic, RNA and protein changes in ageing MSCs in order to understand the age-related functional and biological changes required for their applications in regenerative medicine.
HostingRepository	PRIDE
AnnounceDate	2016-02-16
AnnouncementXML	Submission_2016-02-16_02:25:24.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001952
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Mandy Peffers
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2015-03-19 02:17:57	ID requested
⏵ 1	2016-02-16 02:25:47	announced

Peffers MJ, Collins J, Fang Y, Goljanek-Whysall K, Rushton M, Loughlin J, Proctor C, Clegg PD, Age-related changes in mesenchymal stem cells identified using a multi-omics approach. Eur Cell Mater, 31():136-59(2016) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: human mesenchymal stem cells, label-free quantification

Mandy J Peffers
contact affiliation	Musculoskeletal Biology, Institute of Ageing and Chrionic Disease, University of Liverpool
contact email	peffs@liv.ac.uk
lab head
Mandy Peffers
contact affiliation	University of Liverpool
contact email	peffs@liv.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD001952
     1. Label: PRIDE project
     2. Name: Multi-omics approach to identify age-related changes in mesenchymal stem cells