PXD001952 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Multi-omics approach to identify age-related changes in mesenchymal stem cells |
Description | Mesenchymal stem cells (MSC) are bone-marrow derived cells, capable of multipotent differentiation into connective tissues including bone, tendon and cartilage. They are an attractive source for autologous cell-based treatments for a range of clinical diseases and injuries. MSCs have been demonstrated to possess an age-related loss of cellular functions including differentiation potential and proliferation capacity; with implications for stem cell therapies in older patients. Furthermore the reduction in differentiation potential could contribute to ageing and age-related disease. Biological aging is coupled with a progressive reduction in the regulation of cellular, tissue and organ interaction, resulting in senescence. The purpose of this study was to investigate the epigenetic, RNA and protein changes in ageing MSCs in order to understand the age-related functional and biological changes required for their applications in regenerative medicine. |
HostingRepository | PRIDE |
AnnounceDate | 2016-02-16 |
AnnouncementXML | Submission_2016-02-16_02:25:24.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD001952 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Mandy Peffers |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-03-19 02:17:57 | ID requested | |
⏵ 1 | 2016-02-16 02:25:47 | announced | |
Publication List
Peffers MJ, Collins J, Fang Y, Goljanek-Whysall K, Rushton M, Loughlin J, Proctor C, Clegg PD, Age-related changes in mesenchymal stem cells identified using a multi-omics approach. Eur Cell Mater, 31():136-59(2016) [pubmed] |
Keyword List
curator keyword: Biomedical, Biological |
submitter keyword: human mesenchymal stem cells, label-free quantification |
Contact List
Mandy J Peffers |
contact affiliation | Musculoskeletal Biology, Institute of Ageing and Chrionic Disease, University of Liverpool |
contact email | peffs@liv.ac.uk |
lab head | |
Mandy Peffers |
contact affiliation | University of Liverpool |
contact email | peffs@liv.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/02/PXD001952 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001952
- Label: PRIDE project
- Name: Multi-omics approach to identify age-related changes in mesenchymal stem cells