⮝ Full datasets listing

PXD001950

PXD001950 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleThe heparin-binding proteome in nomal pancreas and murine experimental acute pancreatitis, C4PR_LIV
DescriptionAcute pancreatitis (AP) is an acute inflammation of the pancreas, mainly caused by gallstones and alcohol, and driven by changes in communication between cells. Heparin-binding proteins (HBPs) of the plasma membrane and extracellular matrix play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify the extracellular HBPs in mouse normal pancreas (NP) and in a caerulein mouse model of AP. Many new HBPs (460) were discovered more than doubling their total number to 883. A number of the new HBPs are proteins with well-characterised intracellular functions, e.g. NDUFS4, NDUFS6, but which also have a documented extracellular presence with potential ‘moonlighting’ roles. The HBPs form highly interconnected protein-protein interaction networks in both NP and AP, as well as globally. Thus, HBPs may represent the most interconnected set of extracellular proteins and so those with the greatest regulatory potential. HBPs in NP are associated with biological functions such as molecular transport, cellular movement and tissue architecture that underlie pancreatic homeostasis. However, in AP HBPs are additionally associated with processes such as acute phase response signalling, complement system and mitochondrial dysfunction. By virtue of their extracellular location and heparin binding property, HBPs are easily accessible and are potential biomarkers and drug targets in AP.
HostingRepositoryPRIDE
AnnounceDate2018-12-11
AnnouncementXMLSubmission_2019-06-20_03:37:25.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD001950
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterPhilip Brownridge
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListOxidation; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-03-18 04:57:07ID requested
12018-12-11 06:23:11announced
22019-06-20 03:48:14announcedUpdated publication reference for PubMed record(s): 31211768.
Publication List
Nunes QM, Su D, Brownridge PJ, Simpson DM, Sun C, Li Y, Bui TP, Zhang X, Huang W, Rigden DJ, Beynon RJ, Sutton R, Fernig DG, The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. PLoS One, 14(6):e0217633(2019) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: mouse, pancreas, LCMSMS
Contact List
David G Fernig
contact affiliationInstitute of Integrative Biology Biosciences Building Crown Street University of Liverpool Liverpool L69 7ZB UK
contact emaildgfernig@liverpool.ac.uk
lab head
Philip Brownridge
contact affiliationUniversity of Liverpool
contact emailphilipjb@liv.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2018/12/PXD001950
PRIDE project URI
Repository Record List
[ + ]