PXD001950 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The heparin-binding proteome in nomal pancreas and murine experimental acute pancreatitis, C4PR_LIV |
Description | Acute pancreatitis (AP) is an acute inflammation of the pancreas, mainly caused by gallstones and alcohol, and driven by changes in communication between cells. Heparin-binding proteins (HBPs) of the plasma membrane and extracellular matrix play a central role in cell communication. Therefore, we used heparin affinity proteomics to identify the extracellular HBPs in mouse normal pancreas (NP) and in a caerulein mouse model of AP. Many new HBPs (460) were discovered more than doubling their total number to 883. A number of the new HBPs are proteins with well-characterised intracellular functions, e.g. NDUFS4, NDUFS6, but which also have a documented extracellular presence with potential ‘moonlighting’ roles. The HBPs form highly interconnected protein-protein interaction networks in both NP and AP, as well as globally. Thus, HBPs may represent the most interconnected set of extracellular proteins and so those with the greatest regulatory potential. HBPs in NP are associated with biological functions such as molecular transport, cellular movement and tissue architecture that underlie pancreatic homeostasis. However, in AP HBPs are additionally associated with processes such as acute phase response signalling, complement system and mitochondrial dysfunction. By virtue of their extracellular location and heparin binding property, HBPs are easily accessible and are potential biomarkers and drug targets in AP. |
HostingRepository | PRIDE |
AnnounceDate | 2018-12-11 |
AnnouncementXML | Submission_2019-06-20_03:37:25.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD001950 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Philip Brownridge |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Oxidation; Carbamidomethyl |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2015-03-18 04:57:07 | ID requested | |
1 | 2018-12-11 06:23:11 | announced | |
⏵ 2 | 2019-06-20 03:48:14 | announced | Updated publication reference for PubMed record(s): 31211768. |
Publication List
Nunes QM, Su D, Brownridge PJ, Simpson DM, Sun C, Li Y, Bui TP, Zhang X, Huang W, Rigden DJ, Beynon RJ, Sutton R, Fernig DG, The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis. PLoS One, 14(6):e0217633(2019) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: mouse, pancreas, LCMSMS |
Contact List
David G Fernig |
contact affiliation | Institute of Integrative Biology Biosciences Building Crown Street University of Liverpool Liverpool L69 7ZB UK |
contact email | dgfernig@liverpool.ac.uk |
lab head | |
Philip Brownridge |
contact affiliation | University of Liverpool |
contact email | philipjb@liv.ac.uk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001950
- Label: PRIDE project
- Name: The heparin-binding proteome in nomal pancreas and murine experimental acute pancreatitis, C4PR_LIV