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PXD001904

PXD001904 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleDigital mapping of immunopeptidomes: SWATH-MS
DescriptionWe present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated by SWATH mass spectrometry (MS) from a range a biological sources. This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.
HostingRepositoryPRIDE
AnnounceDate2015-07-14
AnnouncementXMLSubmission_2015-07-14_04:23:13.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterEtienne Caron
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListmonohydroxylated residue
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-03-11 06:52:31ID requested
12015-07-14 04:23:14announced
Publication List
Caron E, Espona L, Kowalewski DJ, Schuster H, Ternette N, Alp, í, zar A, Schittenhelm RB, Ramarathinam SH, Lindestam Arlehamn CS, Chiek Koh C, Gillet LC, Rabsteyn A, Navarro P, Kim S, Lam H, Sturm T, Marcilla M, Sette A, Campbell DS, Deutsch EW, Moritz RL, Purcell AW, Rammensee HG, Stevanovic S, Aebersold R, An open-source computational and data resource to analyze digital maps of immunopeptidomes. Elife, 4():(2015) [pubmed]
Keyword List
curator keyword: Biomedical, Technical
submitter keyword: HLA, immunopeptidome, SWATH-MS, DIA
Contact List
Ruedi Aebersold
contact affiliationETH Zurich Institute of Molecular Systems Biology
contact emailaebersold@imsb.biol.ethz.ch
lab head
Etienne Caron
contact affiliationETH Zurich
contact emailcaron@imsb.biol.ethz.ch
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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