PXD001889

PXD001889 is an original dataset announced via ProteomeXchange.

Title	Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases.
Description	Study: Oxaliplatin-based chemotherapy for colorectal liver metastasis is associated with sinusoidal injury of liver parenchyma and may result in increased morbidity after liver surgery. Preclinical and human liver parenchyma studies have proposed several pathways of oxaliplatin-induced injury, but the effects on protein level remains unknown. Protein expression in liver tissue from eight patients treated with FOLFOX and seven controls without treatment was analyzed by label-free liquid chromatography mass spectrometry. Conclusion: Six weeks after FOLFOX treatment less than 1% of identified proteins showed changes in expression. The changes were associated with DNA replication, cell cycle entry and innate immune response. We hypothesize that the changes are residual after recovery from FOLFOX treatment injury.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:48:49.961.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mario Oroshi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-03-09 02:35:06	ID requested
1	2016-12-21 00:52:31	announced
2	2016-12-22 05:48:48	announced	Updated publication reference for DOI(s): 10.3390/proteomes4040030.
3	2017-05-12 07:12:36	announced	Updated publication reference for DOI(s): 10.3390/proteomes4040030.
⏵ 4	2023-11-14 08:48:51	announced	2023-11-14: Updated project metadata.

Urdzik J, Vildhede A, Wi, ś, niewski JR, Duraj F, Haglund U, Artursson P, Nor, é, n A, Global Proteome Changes in Liver Tissue 6 Weeks after FOLFOX Treatment of Colorectal Cancer Liver Metastases. Proteomes, 4(4):(2016) [pubmed]

curator keyword: Biological

submitter keyword: innate immune response, recovery of liver injury,minichromosome maintenance complex

Jacek R Wisniewski
contact affiliation	Max Planck Institute of Biochemistry
contact email	jwisniew@biochem.mpg.de
lab head
Mario Oroshi
contact affiliation	Proteomics
contact email	oroshi@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/12/PXD001889

PRIDE project URI

• PRIDE
  1. PXD001889
     1. Label: PRIDE project
     2. Name: Global proteome changes in liver tissue 6 weeks after FOLFOX treatment of colorectal cancer liver metastases.