PXD001872

PXD001872 is an original dataset announced via ProteomeXchange.

Title	Digital mapping of immunopeptidomes
Description	We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.
HostingRepository	PRIDE
AnnounceDate	2017-10-24
AnnouncementXML	Submission_2017-10-24_00:18:15.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Etienne Caron
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue
Instrument	TripleTOF 5600; LTQ Orbitrap; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2015-03-06 00:42:55	ID requested
1	2015-07-14 03:29:04	announced
2	2017-06-06 00:30:24	announced	Updated project metadata.
⏵ 3	2017-10-24 00:18:16	announced	Updated project metadata.

Caron E, Espona L, Kowalewski DJ, Schuster H, Ternette N, Alp, í, zar A, Schittenhelm RB, Ramarathinam SH, Lindestam Arlehamn CS, Chiek Koh C, Gillet LC, Rabsteyn A, Navarro P, Kim S, Lam H, Sturm T, Marcilla M, Sette A, Campbell DS, Deutsch EW, Moritz RL, Purcell AW, Rammensee HG, Stevanovic S, Aebersold R, An open-source computational and data resource to analyze digital maps of immunopeptidomes. Elife, 4():(2015) [pubmed]

ProteomeXchange project tag: Human Immuno-Peptidome Project (HUPO-HIPP), Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

curator keyword: Biomedical

submitter keyword: HLA, immunopeptidome, SWATH-MS, DIA

Ruedi Aebersold
contact affiliation	ETH Zurich Institute of Molecular Systems Biology
contact email	aebersold@imsb.biol.ethz.ch
lab head
Etienne Caron
contact affiliation	ETH Zurich
contact email	caron@imsb.biol.ethz.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/07/PXD001872

PRIDE project URI

• PRIDE
  1. PXD001872
     1. Label: PRIDE project
     2. Name: Digital mapping of immunopeptidomes