PXD001839

PXD001839 is an original dataset announced via ProteomeXchange.

Title	Vinculin-network mediated cytoskeletal remodeling regulates contractile function in the aging heart - Rat Data
Description	The human heart is capable of functioning for decades despite minimal cell turnover or regeneration, suggesting that molecular alterations help sustain heart function with age. However, identification of compensatory remodeling events in the aging heart remains elusive. Here we present the proteomes of rhesus monkeys and rats, from which we show that age-associated remodeling of the cardiomyocyte cytoskeleton is highly-conserved and beneficial rather than deleterious. Targeted transcriptomic analysis in Drosophila confirms conservation and implicates vinculin as a unique regulator of cardiac aging. Increased cardiac vinculin expression reinforced the cortical cytoskeleton and enhanced myofilament organization, leading to improved contractility, hemodynamic stress tolerance, and lifespan. These findings suggest that the heart has molecular mechanisms to sustain function and longevity which may be assisted by therapeutic intervention.
HostingRepository	PRIDE
AnnounceDate	2016-04-15
AnnouncementXML	Submission_2016-04-15_07:52:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vidya Venkatraman
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: 10116;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2015-02-24 01:24:06	ID requested
⏵ 1	2016-04-15 07:52:19	announced

Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, Cammarato A, Engler AJ, Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Sci Transl Med, 7(292):292ra99(2015) [pubmed]

curator keyword: Biological, Biomedical

submitter keyword: Cytoskeleton, Drosophila melanogaster, Macacca mulatta, Rattus norvegicus, biomarkers, stiffness, proteomics, mass spectrometry

Dr. Jennifer Van Eyk
contact affiliation	Jennifer Van Eyk, PhD, FAHA and FISHR Director, Advanced Clinical Biosystems Research Institute Professor, Heart Institute and Department of Medicine, Director, Basic Science for the Barbra Streisand Women's Heart Center Erika Glazer Endowed Chair in Women Heart Cedars Sinai Medical Center 127 S. San Vicente Blvd. Advanced Health Science Pavilion A9307 Los Angeles, CA 90048 and Professor, Departments of Medicine and Biological Chemistry, Johns Hopkins University
contact email	Jennifer.VanEyk@cshs.org
lab head
Vidya Venkatraman
contact affiliation	Cedars-Sinai Medical Center
contact email	Vidya.venkatraman@cshs.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/04/PXD001839

PRIDE project URI

• PRIDE
  1. PXD001839
     1. Label: PRIDE project
     2. Name: Vinculin-network mediated cytoskeletal remodeling regulates contractile function in the aging heart - Rat Data