PXD001838

PXD001838 is an original dataset announced via ProteomeXchange.

Title	Proteomics of EBV-infected lytic and refractory cells
Description	Most humans are infected with Epstein-Barr virus (EBV), a cancer-causing virus. While EBV generally persists silently in B lymphocytes, periodic lytic (re-)activation of latent virus is central to its life cycle and to most EBV-related diseases. However, a substantial fraction of EBV-infected B cells and tumor cells in a population is refractory to lytic activation. This resistance to lytic activation directly and profoundly impacts viral persistence and effectiveness of oncolytic therapy for EBV+ cancers. To identify the mechanisms that underlie susceptibility to EBV-lytic activation, we used host protein-expression profiling of separated-lytic and -refractory cells.
HostingRepository	PRIDE
AnnounceDate	2016-04-27
AnnouncementXML	Submission_2016-04-27_13:47:09.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001838
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Jizu Zhi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Dioxidation; 6x(13)C labeled residue; Dehydrated; Ammonia-loss; Acetyl; Carbamidomethyl; Deamidated
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-02-24 00:27:08	ID requested
⏵ 1	2016-04-27 13:47:10	announced

Koganti S, Clark C, Zhi J, Li X, Chen EI, Chakrabortty S, Hill ER, Bhaduri-McIntosh S, Cellular STAT3 functions via PCBP2 to restrain Epstein-Barr Virus lytic activation in B lymphocytes. J Virol, 89(9):5002-11(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: Epstein-Barr virus, lytic activation, proteomic analysis

Sumita Bhaduri-McIntosh
contact affiliation	Pediatric Infectious Diseases Molecular Genetics and Microbiology Stony Brook University Life Sciences Building, Rm. 158 Stony Brook, NY 11794-5222 U.S.A.
contact email	Sumita.Bhaduri-McIntosh@stonybrookmedicine.edu
lab head
Jizu Zhi
contact affiliation	Stony Brook University
contact email	jizu.zhi.2@stonybrook.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/04/PXD001838

PRIDE project URI

• PRIDE
  1. PXD001838
     1. Label: PRIDE project
     2. Name: Proteomics of EBV-infected lytic and refractory cells