PXD001715

PXD001715 is an original dataset announced via ProteomeXchange.

Title	Rod-derived Cone Viability Factor 2
Description	Rod-derived Cone Viability Factor (RdCVF) is a truncated thioredoxin secreted by rod photoreceptors that protects cones. Because the secondary loss of cones in retinitis pigmentosa (RP) is the major visual handicap of this untreatable neurodegenerative disease, the administration of RdCVF is thought to be a promising therapy for RP. We show that RdCVF is acting by binding to Basigin-1 (BSG1) at the surface of cones. BSG1 is an alternative splice product of the BSG gene, a transmembrane protein with an extra immunoglobin domain expressed specifically in the retina. BSG1 binds to the glucose transporter GLUT1. RdCVF increases glucose entry into cones. We found that the increase in glucose is used by cones to induce cell survival by stimulating aerobic glycolysis. A disease associated missense mutation of RdCVF results in its inability to bind to BSG1, to stimulate glucose uptake and to prevent secondary cone death of a model of RP.
HostingRepository	PRIDE
AnnounceDate	2016-06-15
AnnouncementXML	Submission_2016-06-15_08:02:34.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001715
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Francois Delalande
SpeciesList	scientific name: Gallus gallus (Chicken); NCBI TaxID: 9031;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	impact; maXis

Revision	Datetime	Status	ChangeLog Entry
0	2015-01-21 06:04:24	ID requested
⏵ 1	2016-06-15 08:02:35	announced

A, ï, t-Ali N, Fridlich R, Millet-Puel G, Cl, é, rin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, L, é, veillard T, Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell, 161(4):817-32(2015) [pubmed]

curator keyword: Biological

submitter keyword: Gallus Gallus, Maxis, Impact, Retina

Alain Van Dorsselaer
contact affiliation	Laboratoire de Spectrométrie de Masse BioOrganique, IPHC, Université de Strasbourg, CNRS, UMR7178, Strasbourg, France
contact email	vandors@unistra.fr
lab head
Francois Delalande
contact affiliation	CNRS
contact email	delaland@unistra.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/06/PXD001715

PRIDE project URI

• PRIDE
  1. PXD001715
     1. Label: PRIDE project
     2. Name: Rod-derived Cone Viability Factor 2