PXD001681

PXD001681 is an original dataset announced via ProteomeXchange.

Title	HA-mSLX4 wild type and SIMdependent interactors
Description	SUMOylation is known to play important roles in the DNA damage response, however, a role for SUMOylation in interstrand crosslink repair remains enigmatic. We report on the regulation of the SLX4 nuclease scaffold protein by SUMOylation. SLX4 contains three SUMO-Interaction Motifs (SIMs). Mutating all three SIMs abrogated the binding of SLX4 to SUMO-2 and covalent SLX4 SUMOylation. We attempt to identify which protein interaction are SIM dependent.
HostingRepository	PRIDE
AnnounceDate	2015-03-02
AnnouncementXML	Submission_2015-03-02_06:51:59.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Román González-Prieto
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606; scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; phosphorylated residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2015-01-15 01:55:22	ID requested
⏵ 1	2015-03-02 06:52:01	announced

Gonz, á, lez-Prieto R, Cuijpers SA, Luijsterburg MS, van Attikum H, Vertegaal AC, SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites. EMBO Rep, 16(4):512-9(2015) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: SLX4, SUMO, Ubiquitin, DNA Repair, Fanconi Anemia

Alfred C O Vertegaal
contact affiliation	Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, the Netherlands.
contact email	A.C.O.Vertegaal@lumc.nl
lab head
Román González-Prieto
contact affiliation	Leiden University Medical Center (LUMC)
contact email	R.Gonzalez_Prieto@lumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/03/PXD001681

PRIDE project URI

• PRIDE
  1. PXD001681
     1. Label: PRIDE project
     2. Name: HA-mSLX4 wild type and SIMdependent interactors