PXD001676

PXD001676 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Quantitative proteomics analysis of paired colorectal cancer and non-tumorigenic tissues reveal proteins and pathways perturbed in colorectal cancer
Description	Proteomics is a dynamic field emerged dramatically the post genomic era which has been extensively employed to study altered protein expression to gain insight into the development process and pathways involved in cancer and uncover potential protein markers. Membrane proteomes of an expanded cohort of paired CRC and adjacent non-tumorigenic tissues (1 female and 7 males) were profiled using high resolution nanoLC-MS/MS-based proteomics, which identified 1,000-1,300 proteins in each of the two tissue types. 184 proteins were differentially expressed (P < 0.05, fold change > 1.5); 69 proteins were up- regulated and 115 proteins were down-regulated in the CRC tissues relative to non-tumorigenic tissues.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_04:22:35.472.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manveen Sethi
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2015-01-14 01:25:28	ID requested
1	2016-06-15 08:32:56	announced
⏵ 2	2024-10-22 04:22:40	announced	2024-10-22: Updated project metadata.

Publication List

10.1016/j.jprot.2015.05.037;
Sethi MK, Thaysen-Andersen M, Kim H, Park CK, Baker MS, Packer NH, Paik YK, Hancock WS, Fanayan S, Quantitative proteomic analysis of paired colorectal cancer and non-tumorigenic tissues reveals signature proteins and perturbed pathways involved in CRC progression and metastasis. J Proteomics, 126():54-67(2015) [pubmed]

10.1016/j.jprot.2015.05.037;

Sethi MK, Thaysen-Andersen M, Kim H, Park CK, Baker MS, Packer NH, Paik YK, Hancock WS, Fanayan S, Quantitative proteomic analysis of paired colorectal cancer and non-tumorigenic tissues reveals signature proteins and perturbed pathways involved in CRC progression and metastasis. J Proteomics, 126():54-67(2015) [pubmed]

Keyword List

ProteomeXchange project tag: Chromosome-centric Human Proteome Project (C-HPP), Human Proteome Project
curator keyword: Biomedical
submitter keyword: proteomics, mass spectrometery,Colorectal Cancer, LC-MS/MS

ProteomeXchange project tag: Chromosome-centric Human Proteome Project (C-HPP), Human Proteome Project

curator keyword: Biomedical

submitter keyword: proteomics, mass spectrometery,Colorectal Cancer, LC-MS/MS

Contact List

Dr. Susan Fanayan
contact affiliation	Macquarie University
contact email	susan.fanayan@mq.edu.au
lab head
Manveen Sethi
contact affiliation	Macquarie University
contact email	manveen.sethi1986@gmail.com
dataset submitter

Full Dataset Link List

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PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/06/PXD001676

PRIDE project URI

Repository Record List

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