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PXD001674

PXD001674 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleImmune suppressive neutrophils are a separate subset developing parallel to normal neutrophils
DescriptionRelease of neutrophil subsets (hypersegmented, mature and banded) into the bloodstream was evoked by acute inflammation induced by iv. Injection of 2ng/kg lipopolysaccharide in healthy human volunteers pulse (6 hrs) labelled with deuteriated glucose. Three hours after injection, the three neutrophil subsets were sorted from blood. Incorporation of label into DNA was measured and proteome profiles were determined using high-end proteomics techniques (dimethyl labeling, SCX, nano-uplc, Q-Exactive).
HostingRepositoryPRIDE
AnnounceDate2017-05-29
AnnouncementXMLSubmission_2017-05-29_05:46:08.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD001674
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterPatrick Wijten
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListdihydroxylated residue; 2x(13)C: 6x(2)H labeled dimethylated L-arginine; monohydroxylated residue; formylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02015-01-14 01:24:36ID requested
12017-05-29 05:46:09announced
Publication List
Tak T, Wijten P, Heeres M, Pickkers P, Scholten A, Heck AJR, Vrisekoop N, Leenen LP, Borghans JAM, Tesselaar K, Koenderman L, neutrophils identified as a separate subset by proteome profiling and in vivo pulse-chase labeling. Blood, 129(26):3476-3485(2017) [pubmed]
Keyword List
curator keyword: Biomedical
submitter keyword: Human, Neutrophils, LC-MS
Contact List
Albert Heck
contact affiliationBiomolecular Mass Spectrometry and Proteomics Group, Utrecht University, The Netherlands
contact emailA.J.R.Heck@uu.nl
lab head
Patrick Wijten
contact affiliationFaculty of Science
contact emailP.wijten@uu.nl
dataset submitter
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Dataset FTP location
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PRIDE project URI
Repository Record List
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