PXD001622 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Elucidating the Linezolid response of Staphylococcus aureus USA300 (metabolic labelling) |
Description | The translation inhibitor Linezolid is an important antibiotic of last resort against multiresistant gram-positive pathogens including MRSA. Linezolid is reported to specifically inhibit extracellular virulence factors, but the molecular cause is unknown. To elucidate the physiological response of S. aureus to Linezolid in general and the possible inhibition of virulence factors specifically we performed a holistic study. We added Linezolid to logarithmically growing S. aureus cells and analysed the Linezolid stress response with transcriptomics, quantitative proteomics and microscopy experiments. |
HostingRepository | PRIDE |
AnnounceDate | 2016-03-21 |
AnnouncementXML | Submission_2016-03-22_03:10:34.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Florian Bonn |
SpeciesList | scientific name: Staphylococcus aureus (strain USA300); NCBI TaxID: 367830; |
ModificationList | monohydroxylated residue |
Instrument | LTQ Orbitrap |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-12-19 01:27:54 | ID requested | |
1 | 2016-03-21 01:13:41 | announced | |
⏵ 2 | 2016-03-22 03:10:35 | announced | Updated publication reference for PubMed record(s): 26996810. |
Publication List
Bonn F, Pan, é, -Farr, é J, Schl, ü, ter R, Schaffer M, Fuchs S, Bernhardt J, Riedel K, Otto A, V, ö, lker U, van Dijl JM, Hecker M, M, ä, der U, Becher D, Global analysis of the impact of linezolid onto virulence factor production in S. aureus USA300. Int J Med Microbiol, 306(3):131-40(2016) [pubmed] |
Keyword List
curator keyword: Biomedical |
submitter keyword: Staphylococcus aureus, Linezolid, Transertion, metabolic labelling |
Contact List
Dörte Becher |
contact affiliation | University of Greifswald |
contact email | dbecher@uni-greifswald.de |
lab head | |
Florian Bonn |
contact affiliation | University of Greifswald |
contact email | fbonn@uni-greifswald.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2016/03/PXD001622 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001622
- Label: PRIDE project
- Name: Elucidating the Linezolid response of Staphylococcus aureus USA300 (metabolic labelling)