PXD001572

PXD001572 is an original dataset announced via ProteomeXchange.

Title	Interactome analysis of PYHIN immune regulators
Description	The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here, we provide the interaction network for all PYHIN proteins. By designing a cell-based inducible system and integrating microscopy, immunoaffinity capture, quantitative mass spectrometry, and bioinformatics, we identified over 300 PYHIN interactions reflective of diverse functions.
HostingRepository	PRIDE
AnnounceDate	2015-03-12
AnnouncementXML	Submission_2015-03-12_07:07:01.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001572
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	T Greco
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	Oxidation; Phospho; Gln->pyro-Glu; Dehydrated; Ammonia-loss; Glu->pyro-Glu; Acetyl; Carbamidomethyl; Deamidated
Instrument	LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2014-12-04 02:21:51	ID requested
⏵ 1	2015-03-12 07:07:02	announced

Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM, The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol Syst Biol, 11(1):787(2015) [pubmed]

curator keyword: Biomedical

submitter keyword: DNA sensing, protein interactions, IFIX

Ileana M Cristea
contact affiliation	Department of Molecular Biology, Princeton University, USA
contact email	icristea@princeton.edu
lab head
T Greco
contact affiliation	Molecular Biology
contact email	tgreco@princeton.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD001572
     1. Label: PRIDE project
     2. Name: Interactome analysis of PYHIN immune regulators