PXD001549

PXD001549 is an original dataset announced via ProteomeXchange.

Title	Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome
Description	We used stable isotope labeling and antibody-based peptide enrichment to quantify more than 1500 protein sites modified with a Gly-Gly motif, the remnant of ubiquitination, in human T-cells treated with an Hsp90 inhibitor. We compared the data with the evolution of net protein levels in the same cells and with changes in protein decay and synthesis rates from a previous study.
HostingRepository	PRIDE
AnnounceDate	2015-03-19
AnnouncementXML	Submission_2015-04-01_05:16:34.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfredo Quadroni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	iodoacetic acid derivatized residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap; LTQ Orbitrap Velos

Revision	Datetime	Status	ChangeLog Entry
0	2014-11-27 07:22:28	ID requested
1	2015-03-19 04:45:03	announced
⏵ 2	2015-04-01 05:16:35	announced	Updated publication reference for PubMed record(s): 25782750.

Quadroni M, Potts A, Waridel P, Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome. J Proteomics, 120():215-29(2015) [pubmed]

curator keyword: Biological

submitter keyword: chaperones, hsp90, protein folding, stress, ubiquitin, protein synthesis ,protein degradation, mass spectrometry, SILAC, quantitation

Manfredo Quadroni
contact affiliation	Protein Analysis Facility Center for Integrative Genomics University of Lausanne 1015 LAUSANNE - SWITZERLAND
contact email	manfredo.quadroni@unil.ch
lab head
Manfredo Quadroni
contact affiliation	University of Lausanne
contact email	manfredo.quadroni@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/03/PXD001549

PRIDE project URI

• PRIDE
  1. PXD001549
     1. Label: PRIDE project
     2. Name: Hsp90 inhibition induces both protein-specific and global changes in the ubiquitinome