PXD001370

PXD001370 is an original dataset announced via ProteomeXchange.

Title	Aging Mouse Brain Mitochondria LC-MS/MS
Description	This study investigates the proteomic alterations in brain mitochondria isolated from 5- (mature), 12- (old), and 24-month-old (aged) mice to examine normal "healthy" aging. Using quantitative mass-spectrometry based super-SILAC, our findings revealed global proteomic changes in brain mitochondria identifying several metabolic pathways including glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation. Overall, we found that the bioenergetic function of these mitochondria was preserved suggesting the proteomic alterations potentially allow for compensatory mechanisms to combat aging.
HostingRepository	PRIDE
AnnounceDate	2015-01-27
AnnouncementXML	Submission_2015-01-27_02:33:18.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Kelly Stauch
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2014-09-30 05:56:54	ID requested
⏵ 1	2015-01-27 02:33:19	announced

Stauch KL, Purnell PR, Villeneuve LM, Fox HS, Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism. Proteomics, 15(9):1574-86(2015) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: Mouse, Mitochondria, TTOF 5600

Howard Fox
contact affiliation	University of Nebraska Medical Center
contact email	hfox@unmc.edu
lab head
Kelly Stauch
contact affiliation	University of Nebraska Medical Center
contact email	kelly.stauch@unmc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2015/01/PXD001370

PRIDE project URI

• PRIDE
  1. PXD001370
     1. Label: PRIDE project
     2. Name: Aging Mouse Brain Mitochondria LC-MS/MS