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PXD001354

PXD001354 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleHepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals
DescriptionPharmaceuticals are pseudo persistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to Acetaminophen: 54.77 ± 34.67; Atenolol: 11.08 ± 7.98 and Carbamazepine: 7.85 ± 0.13 µg•L-1 for 5 days. After Acetaminophen treatment, 19 proteins were differently expressed, of which 11 were significant with respect to the control group (eight up-regulated and three down-regulated). After Atenolol treatment, 7 differently expressed proteins were obtained in comparison with the control, of which 6 could be identified (four up-regulated and 2 down-regulated). Carbamazepine exposure resulted in 15 differently expressed proteins compared with the control, with 10 of them identified (seven up-regulated and three down-regulated). Out of these, 3 features were common between Acetaminophen and Carbamazepine and one between Carbamazepine and Atenolol. One feature was common across all treatments. Principal component analysis and heat map clustering showed a clear grouping of the variability due to the applied treatments. The obtained data suggest (1) that exposure to environmentally relevant concentrations of the pharmaceuticals alters the hepatic protein expression profile of the Atlantic salmon; and (2) the existence of treatment specific processes that may be useful for biomarker development.
HostingRepositoryPRIDE
AnnounceDate2014-11-18
AnnouncementXMLSubmission_2014-11-18_08:29:12.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD001354
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterMiriam Hampel
SpeciesList scientific name: Salmo sp.; NCBI TaxID: 8031;
ModificationListNo PTMs are included in the dataset
Instrument4800 Proteomics Analyzer
Dataset History
RevisionDatetimeStatusChangeLog Entry
02014-09-22 04:08:52ID requested
12014-11-18 01:11:14announced
22014-11-18 08:29:13announcedUpdated publication details.
Publication List
Hampel M, Alonso E, Aparicio I, Santos JL, Leaver M, Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals. Mol Cell Proteomics, 14(2):371-81(2015) [pubmed]
Keyword List
curator keyword: Biological
submitter keyword: Salmon liver
pharmaceuticals
environmental levels
LC-MSMS
Contact List
Jesus Forja
contact affiliationJ. Forja Dpt. Physical Chemistry CACYTMAR Campus de Excelencia Internacional del Mar University of Cadiz (Spain)
contact emailjesus.forja@uca.es
lab head
Miriam Hampel
contact affiliationUniversity of Cádiz
contact emailmiriam.hampel@uca.es
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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