PXD001354 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals |
Description | Pharmaceuticals are pseudo persistent aquatic pollutants with unknown effects at environmentally relevant concentrations. Atlantic salmon (Salmo salar) were exposed to Acetaminophen: 54.77 ± 34.67; Atenolol: 11.08 ± 7.98 and Carbamazepine: 7.85 ± 0.13 µg•L-1 for 5 days. After Acetaminophen treatment, 19 proteins were differently expressed, of which 11 were significant with respect to the control group (eight up-regulated and three down-regulated). After Atenolol treatment, 7 differently expressed proteins were obtained in comparison with the control, of which 6 could be identified (four up-regulated and 2 down-regulated). Carbamazepine exposure resulted in 15 differently expressed proteins compared with the control, with 10 of them identified (seven up-regulated and three down-regulated). Out of these, 3 features were common between Acetaminophen and Carbamazepine and one between Carbamazepine and Atenolol. One feature was common across all treatments. Principal component analysis and heat map clustering showed a clear grouping of the variability due to the applied treatments. The obtained data suggest (1) that exposure to environmentally relevant concentrations of the pharmaceuticals alters the hepatic protein expression profile of the Atlantic salmon; and (2) the existence of treatment specific processes that may be useful for biomarker development. |
HostingRepository | PRIDE |
AnnounceDate | 2014-11-18 |
AnnouncementXML | Submission_2014-11-18_08:29:12.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD001354 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Miriam Hampel |
SpeciesList | scientific name: Salmo sp.; NCBI TaxID: 8031; |
ModificationList | No PTMs are included in the dataset |
Instrument | 4800 Proteomics Analyzer |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2014-09-22 04:08:52 | ID requested | |
1 | 2014-11-18 01:11:14 | announced | |
⏵ 2 | 2014-11-18 08:29:13 | announced | Updated publication details. |
Publication List
Hampel M, Alonso E, Aparicio I, Santos JL, Leaver M, Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals. Mol Cell Proteomics, 14(2):371-81(2015) [pubmed] |
Keyword List
curator keyword: Biological |
submitter keyword: Salmon liver |
pharmaceuticals |
environmental levels |
LC-MSMS |
Contact List
Jesus Forja |
contact affiliation | J. Forja Dpt. Physical Chemistry CACYTMAR Campus de Excelencia Internacional del Mar University of Cadiz (Spain) |
contact email | jesus.forja@uca.es |
lab head | |
Miriam Hampel |
contact affiliation | University of Cádiz |
contact email | miriam.hampel@uca.es |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD001354
- Label: PRIDE project
- Name: Hepatic proteome analysis of Atlantic salmon (Salmo salar) after exposure to environmental concentrations of human pharmaceuticals