PXD001344

PXD001344 is an original dataset announced via ProteomeXchange.

Title	Inactivation of a NB-LRR plant immune-effector complex by post-translational modification
Description	Modification of plant immune complexes by pathogen effectors can trigger strong immune responses mediated by the action of nucleotide binding-leucine rich repeat immune receptors. Although some strains of the pathogen Pseudomonas syringae harbor effectors that individually can trigger immunity, the plant’s response may be suppressed by other virulence factors. This work shows a new strategy for immune suppression. After injection into host cells, the suppressing effector binds to and acetylates multiple members of an immune complex, including another effector that on its own can trigger immunity. Acetylations modify serine, threonine, lysine and/or histidine residues in the targets resulting in the inactivation of the whole immune complex and increased growth of the pathogen.
HostingRepository	PRIDE
AnnounceDate	2016-05-04
AnnouncementXML	Submission_2016-05-04_07:48:13.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD001344
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Donald Wolfgeher
SpeciesList	scientific name: Pseudomonas syringae; NCBI TaxID: 317; scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702;
ModificationList	Oxidation; Phospho; Delta:H(4)C(2)O(-1)S(1); Dehydrated; Ammonia-loss; Formyl; Acetyl; Ethanolyl; Carbamidomethyl
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2014-09-18 08:30:35	ID requested
⏵ 1	2016-05-04 07:48:16	announced

Lee J, Manning AJ, Wolfgeher D, Jelenska J, Cavanaugh KA, Xu H, Fernandez SM, Michelmore RW, Kron SJ, Greenberg JT, Acetylation of an NB-LRR Plant Immune-Effector Complex Suppresses Immunity. Cell Rep, 13(8):1670-82(2015) [pubmed]

curator keyword: Biological

submitter keyword: Q-Exactive, Acetylation, Mass Spectrometry, Arabidopsis thaliana, Pseudomonas syringae

Jean T. Greenberg
contact affiliation	Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA
contact email	jgreenbe@uchicago.edu
lab head
Donald Wolfgeher
contact affiliation	University of Chicago
contact email	donw@uchicago.edu
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD001344
     1. Label: PRIDE project
     2. Name: Inactivation of a NB-LRR plant immune-effector complex by post-translational modification