PXD001342

PXD001342 is an original dataset announced via ProteomeXchange.

Title	Soluble lymph node proteome during anthrax infection in mice
Description	This study aimed to characterize a soluble proteome of popliteal lymph nodes during lymphadenitis induced by intradermal injection of Bacillus anthracis Sterne spores in mice using tandem LC-MS/MS. More than 380 proteins were detected in the normal intra-nodal lymph, while the infectious process resulted in the profound changes in the protein abundances and appearance of 297 unique proteins. These proteins belong to an array of processes reflecting response to wounding, inflammation and perturbations of hemostasis, innate immune response, coagulation and fibrinolysis, regulation of body fluid levels and vascular disturbance among others. The results demonstrate that the proteome of intra-nodal lymph serves as a sensitive sentinel of the processes occurring within the lymph nodes during infection. The acute innate response of the lymph nodes to anthrax is accompanied by cellular damage and inflammation with a large number of up- and down-regulated proteins many of which are distinct from those detected in serum.
HostingRepository	PRIDE
AnnounceDate	2014-10-21
AnnouncementXML	Submission_2014-10-21_06:11:44.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Serguei Popov
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2014-09-18 01:40:38	ID requested
⏵ 1	2014-10-21 06:11:46	announced

Popova TG, Espina V, Zhou W, Mueller C, Liotta L, Popov SG, Whole proteome analysis of mouse lymph nodes in cutaneous anthrax. PLoS One, 9(10):e110873(2014) [pubmed]

curator keyword: Biomedical, Biological

submitter keyword: lymph, proteome, lymph node, anthrax, mice

Serguei Popov
contact affiliation	George Mason University, VA
contact email	spopov@gmu.edu
lab head
Serguei Popov
contact affiliation	George Mason University, VA
contact email	spopov@gmu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2014/10/PXD001342

PRIDE project URI

• PRIDE
  1. PXD001342
     1. Label: PRIDE project
     2. Name: Soluble lymph node proteome during anthrax infection in mice